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Csi1 links centromeres to the nuclear envelope for centromere clustering

• Haitong Hou, Zhou Zhou, +6 authors Songtao Jia
• The Journal of cell biology
• 2012

In the fission yeast Schizosaccharomyces pombe, the centromeres of each chromosome are clustered together and attached to the nuclear envelope near the site of the spindle pole body during… (More)

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.

• Yu Lin Wang, Scott Kallgren, +11 authors Songtao Jia
• The Journal of biological chemistry
• 2012

Histone lysine acetylation has emerged as a key regulator of genome organization. However, with a few exceptions, the contribution of each acetylated lysine to cellular functions is not well… (More)

Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.

• Haitong Hou, Yu Wang, Scott Kallgren, James Thompson, John R. Yates, Songtao Jia
• The Journal of biological chemistry
• 2010

The incorporation of histone variant H2A.Z into nucleosomes plays essential roles in regulating chromatin structure and gene expression. A multisubunit complex containing chromatin remodeling protein… (More)

The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast

• Scott Kallgren, Stuart Andrews, +6 authors Songtao Jia
• PLoS genetics
• 2014

Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation. The RNAi machinery is required… (More)

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

• Elizabeth C. Townsend, Mark A. Murakami, +94 authors David M. Weinstock
• Cancer cell
• 2016

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice… (More)

Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

• Xavier Tadeo, Jiyong Wang, +4 authors Songtao Jia
• Genes & development
• 2013

The RNAi pathway is required for heterochromatin assembly at repetitive DNA elements in diverse organisms. In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising gene… (More)

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

• Elizabeth C. Townsend, Mark A. Murakami, +94 authors David M. Weinstock
• Cancer cell
• 2016

Elizabeth C. Townsend, Mark A. Murakami, Alexandra Christodoulou, Amanda L. Christie, Johannes Köster, Tiffany A. DeSouza, Elizabeth A. Morgan, Scott P. Kallgren, Huiyun Liu, Shuo-Chieh Wu, Olivia… (More)

Supplemental Information Spt 5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation

• Ameet Shetty, Scott Kallgren, +6 authors Fred Winston
• 2017

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.

• Ameet Shetty, Scott Kallgren, +6 authors Fred Winston
• Molecular cell
• 2017

Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood.… (More)

Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance

• Wenzhu Li, Jia Yi, +5 authors Xiangwei He
• PLoS genetics
• 2017

The fidelity of epigenetic inheritance or, the precision by which epigenetic information is passed along, is an essential parameter for measuring the effectiveness of the process. How the precision… (More)

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