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- Publications
- Influence
Csi1 links centromeres to the nuclear envelope for centromere clustering
- Haitong Hou, Z. Zhou, +6 authors S. Jia
- Biology, Medicine
- The Journal of cell biology
- 26 November 2012
Csi1 promotes centromere clustering by linking centromeres to the SUN domain protein Sad1 in the nuclear envelope.
Histone H3 Lysine 14 Acetylation Is Required for Activation of a DNA Damage Checkpoint in Fission Yeast*
- Y. Wang, Scott Kallgren, +11 authors S. Jia
- Biology, Medicine
- The Journal of Biological Chemistry
- 19 December 2011
Background: Histone acetylation regulates diverse cellular processes. Results: The fission yeast Mst2 complex is a specific histone H3 lysine 14 acetyltransferase. Conclusion: H3K14 acetylation is… Expand
Histone Variant H2A.Z Regulates Centromere Silencing and Chromosome Segregation in Fission Yeast*
- Haitong Hou, Y. Wang, Scott Kallgren, J. Thompson, J. Yates, S. Jia
- Biology, Medicine
- The Journal of Biological Chemistry
- 12 November 2009
The incorporation of histone variant H2A.Z into nucleosomes plays essential roles in regulating chromatin structure and gene expression. A multisubunit complex containing chromatin remodeling protein… Expand
Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.
- Ameet Shetty, Scott Kallgren, +6 authors F. Winston
- Biology, Medicine
- Molecular cell
- 6 April 2017
Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood.… Expand
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
- Elizabeth C. Townsend, M. Murakami, +94 authors D. Weinstock
- Medicine
- Cancer cell
- 11 April 2016
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice… Expand
Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.
- X. Tadeo, Jiyong Wang, +4 authors S. Jia
- Biology, Medicine
- Genes & development
- 15 November 2013
The RNAi pathway is required for heterochromatin assembly at repetitive DNA elements in diverse organisms. In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising gene… Expand
The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast
- Scott Kallgren, S. Andrews, +6 authors S. Jia
- Biology, Medicine
- PLoS genetics
- 1 May 2014
Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation. The RNAi machinery is required… Expand
Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance
The fidelity of epigenetic inheritance or, the precision by which epigenetic information is passed along, is an essential parameter for measuring the effectiveness of the process. How the precision… Expand
Csi1 illuminates the mechanism and function of Rabl configuration
- Haitong Hou, Scott Kallgren, S. Jia
- Biology, Medicine
- Nucleus
- 1 May 2013
The nuclear envelope not only compartmentalizes the genome but is also home to the SUN-KASH domain proteins, which play essential roles both in genome organization and in linking the nucleus to the… Expand
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
- Elizabeth C. Townsend, M. Murakami, +94 authors D. Weinstock
- Medicine, Biology
- Cancer cell
- 11 July 2016
Elizabeth C. Townsend, Mark A. Murakami, Alexandra Christodoulou, Amanda L. Christie, Johannes Köster, Tiffany A. DeSouza, Elizabeth A. Morgan, Scott P. Kallgren, Huiyun Liu, Shuo-Chieh Wu, Olivia… Expand