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Csi1 links centromeres to the nuclear envelope for centromere clustering
Csi1 promotes centromere clustering by linking centromeres to the SUN domain protein Sad1 in the nuclear envelope.
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Histone H3 Lysine 14 Acetylation Is Required for Activation of a DNA Damage Checkpoint in Fission Yeast*
Background: Histone acetylation regulates diverse cellular processes. Results: The fission yeast Mst2 complex is a specific histone H3 lysine 14 acetyltransferase. Conclusion: H3K14 acetylation isExpand
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Histone Variant H2A.Z Regulates Centromere Silencing and Chromosome Segregation in Fission Yeast*
The incorporation of histone variant H2A.Z into nucleosomes plays essential roles in regulating chromatin structure and gene expression. A multisubunit complex containing chromatin remodeling proteinExpand
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Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.
Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood.Expand
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in miceExpand
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Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.
The RNAi pathway is required for heterochromatin assembly at repetitive DNA elements in diverse organisms. In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising geneExpand
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The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast
Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation. The RNAi machinery is requiredExpand
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Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance
The fidelity of epigenetic inheritance or, the precision by which epigenetic information is passed along, is an essential parameter for measuring the effectiveness of the process. How the precisionExpand
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Csi1 illuminates the mechanism and function of Rabl configuration
The nuclear envelope not only compartmentalizes the genome but is also home to the SUN-KASH domain proteins, which play essential roles both in genome organization and in linking the nucleus to theExpand
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Elizabeth C. Townsend, Mark A. Murakami, Alexandra Christodoulou, Amanda L. Christie, Johannes Köster, Tiffany A. DeSouza, Elizabeth A. Morgan, Scott P. Kallgren, Huiyun Liu, Shuo-Chieh Wu, OliviaExpand
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