Learn More
MscL is a channel that opens a large pore in the Escherichia coli cytoplasmic membrane in response to mechanical stress. Previously, we highly enriched the MscL protein by using patch clamp as a functional assay and cloned the corresponding gene. The predicted protein contains a largely hydrophobic core spanning two-thirds of the molecule and a more(More)
The advent of gadolinium-based "hepatobiliary" contrast agents offers new opportunities for diagnostic magnetic resonance imaging (MRI) and has triggered great interest for innovative imaging approaches to the liver and bile ducts. In this review article we discuss the imaging properties of the two gadolinium-based hepatobiliary contrast agents currently(More)
PURPOSE To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS 3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise performance and spatial resolution were(More)
PURPOSE To evaluate the signal to noise ratio (SNR) and contrast to noise ratio (CNR) performance of 0.05 mmol/kg gadoxetic acid and 0.1 mmol/kg gadobenate dimeglumine for dynamic and hepatobiliary phase imaging. In addition, flip angles (FA) that maximize relative contrast-to-noise performance for hepatobiliary phase imaging were determined. MATERIALS(More)
This article reviews the magnetic resonance imaging (MRI) and angiography (MRA) techniques, imaging findings, and evidence for evaluating patients with acute chest pain due to acute pulmonary embolus (PE), aortic dissection (AD), and myocardial infarction (MI). When computed tomographic angiography (CTA) is contraindicated, MRI and MRA are important(More)
PURPOSE To determine the effectiveness of MR angiography for pulmonary embolism (MRA-PE) in symptomatic patients. MATERIALS AND METHODS We retrospectively reviewed all patients whom were evaluated for possible pulmonary embolism (PE) using MRA-PE. A 3-month and 1-year from MRA-PE electronic medical record (EMR) review was performed. Evidence for venous(More)
With conventional Fourier transform (FT) magnetic resonance imaging (MRI), it is difficult to perform contrast-enhanced three-dimensional (3D) MR angiography (MRA) with the temporal and spatial resolution necessary to depict the carotid arteries. However, locally focused (LF) MRI is a more efficient method that utilizes prior knowledge of the image content(More)
Traditional Fourier MR imaging (FT MRI) utilizes the Whittaker-Kotel'nikov-Shannon (WKS) sampling theorem. This theorem specifies the spatial frequency components which need to be measured to reconstruct an image with a known field of view (FOV). In this paper, we generalize this result in order to find the optimal k-space sampling for images that vanish(More)
PURPOSE To determine optimal delay times and flip angles for T1-weighted hepatobiliary imaging at 1.5 Tesla (T) with gadoxetic acid and to demonstrate the feasibility of using a high-resolution navigated optimized T1-weighted pulse sequence to evaluate biliary disease. MATERIALS AND METHODS Eight healthy volunteers were scanned at 1.5T using a T1-weighted(More)
Geometric distortions and poor image resolution are well known shortcomings of single-shot echo-planar imaging (ss-EPI). Yet, due to the motion immunity of ss-EPI, it remains the most common sequence for diffusion-weighted imaging (DWI). Moreover, both navigated DW interleaved EPI (iEPI) and parallel imaging (PI) methods, such as sensitivity encoding(More)