Scott J. Andrews

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Brain inflammation is a double-edged sword. It is required for brain repair in acute damage, whereas chronic inflammation and autoimmune disorders are neuropathogenic. Certain proinflammatory cytokines and chemokines are closely related to cognitive dysfunction and neurodegeneration. Representative anti-inflammatory cytokines, such as interleukin (IL)-10,(More)
Combined antiretroviral therapy (ART) tremendously improved the lifespan and symptoms associated with AIDS-defining illness in affected individuals. However, chronic ART-treated patients frequently develop age-dependent complications, including dementia, diabetes, and hyperlipidemia: all risk factors of Alzheimer’s disease. Importantly, the effect of ART(More)
The activity of G6PD was examined by spectrophotometric and electrophoretic assays in cell fractions from the testes of mice at different ages (5-62 days). (1) The G6PD activity of the cells of the seminiferous tubule was as high or higher than that of the interstitial tissue. (2) The high G6PD activity of the testis of the immature mouse was mainly due to(More)
Lactate dehydrogenase (LDH) C, activity was observed in testis extracts from normal mice but was progressively reduced in mice carrying the male-sterile translocations T31H, T32H, T37H, T38H, T40H and T42H, with no detectable activity being observed in the last two mice. None of the vesicular gland extracts from these male-steriles showed LDH-C4 activity,(More)
The specific activity of G6PD and PGK were measured in the testes, seminal vesicles, and livers of Sxr/+,XX mice, their Sxr/+,XY littermates and normal mice. While G6PD activity was high in the testes of young normal mice and declined as the testes matured, in the testes of Sxr/+,XX mice activity remained high, suggesting a failure of the Sertoli cells to(More)
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