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- Scott E. Counts, Elliott Jay Mufson
- Journal of neuropathology and experimental…
- 2005
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (NB) cholinergic… (More)
- Elliott Jay Mufson, Scott E. Counts, Sylvia E. Perez, Stephen D Ginsberg
- Expert review of neurotherapeutics
- 2008
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced cortical choline… (More)
- Scott E. Counts, Elliott Jay Mufson
- Journal of neurochemistry
- 2010
Degeneration of locus coeruleus (LC) noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The physiological consequences of this phenomenon are unclear, but… (More)
- Elliott Jay Mufson, Scott E. Counts, Stephen D Ginsberg
- Neurochemical Research
- 2002
Cholinergic neurons of the nucleus basalis (NB) are selectively vulnerable in Alzheimer's disease (AD), yet the molecular mechanisms associated with their dysfunction remain unknown. We used single… (More)
- Stephen D Ginsberg, Melissa J. Alldred, +8 authors Shaoli Che
- Biological psychiatry
- 2010
BACKGROUND
Endocytic dysfunction and neurotrophin signaling deficits may underlie the selective vulnerability of hippocampal neurons during the progression of Alzheimer's disease (AD), although there… (More)
- Scott E. Counts, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, H Uri Saragovi, Elliott Jay Mufson
- Annals of neurology
- 2004
Degeneration of cholinergic nucleus basalis (NB) cortical projection neurons is associated with cognitive decline in late-stage Alzheimer's disease (AD). NB neuron survival is dependent on… (More)
- Stephen D Ginsberg, Elliott Jay Mufson, +4 authors Shaoli Che
- Journal of Alzheimer's disease : JAD
- 2010
Endocytic alterations are one of the earliest changes to occur in Alzheimer's disease (AD), and are hypothesized to be involved in the selective vulnerability of specific neuronal populations during… (More)
- Scott E. Counts, Muhammad Nadeem, Shivanand P. Lad, Joanne Wuu, Elliott Jay Mufson
- Journal of neuropathology and experimental…
- 2006
Alterations in synaptic protein stoichiometry may contribute to neocortical synaptic dysfunction in Alzheimer disease (AD). Whether perturbations in synaptic protein expression occur during the… (More)
- Scott E. Counts, Melissa J. Alldred, Shaoli Che, Stephen D Ginsberg, Elliott Jay Mufson
- Neuropharmacology
- 2014
Clinical neuropathologic studies suggest that the selective vulnerability of hippocampal CA1 pyramidal projection neurons plays a key role in the onset of cognitive impairment during the early phases… (More)
- Scott E. Counts, Sylvia E. Perez, Stephen D Ginsberg, Sonsoles de Lacalle, Elliott Jay Mufson
- Molecular interventions
- 2003
Galanin (GAL) and GAL receptors (GALR) are overexpressed in limbic brain regions associated with cognition in Alzheimer disease (AD). The functional consequences of this overexpression are unclear.… (More)