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  • Xinxin Wang, Scott E. Boyken, +6 authors Yina Hsing Huang
  • Biology, Medicine
  • Science Signaling
  • 2014 (First Published: 5 August 2014)
  • Precise regulation of the kinetics and magnitude of Ca2+ signaling enables this signal to mediate diverse responses, such as cell migration, differentiation, vesicular trafficking, and cell death. WeContinue Reading
  • Scott E. Boyken, D. Bruce Fulton, Amy H. Andreotti
  • Chemistry, Medicine
  • Protein science : a publication of the Protein…
  • 2012 (First Published: 1 September 2012)
  • IL-2 inducible T-cell kinase (Itk) is a Tec family non-receptor tyrosine kinase involved in signaling downstream of the T-cell receptor. Itk contains an amino-terminal Pleckstrin Homology (PH) domainContinue Reading
  • Amanda M Sparkman, Tonia S Schwartz, +4 authors Anne M. Bronikowski
  • Biology, Medicine
  • General and comparative endocrinology
  • 2012 (First Published: 1 August 2012)
  • Insulin-like growth factor-1 (IGF-1) is a member of the vertebrate insulin/insulin-like growth factor/relaxin gene family necessary for growth, reproduction, and survival at both the cellular andContinue Reading
  • Sujan Devkota, Raji E. Joseph, Scott E. Boyken, D. Bruce Fulton, Amy H. Andreotti
  • Chemistry, Medicine
  • Biochemistry
  • 2017 (First Published: 13 June 2017)
  • Pleckstrin homology (PH) domains are well-known as phospholipid binding modules, yet evidence that PH domain function extends beyond lipid recognition is mounting. In this work, we characterize aContinue Reading