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  • Wayne W. L. Chan, Scott C. Wise, +24 authors Daniel L. Flynn
  • Biology, Medicine
  • Cancer cell
  • 2011 (First Published: 1 April 2011)
  • Acquired resistance to ABL1 tyrosine kinase inhibitors (TKIs) through ABL1 kinase domain mutations, particularly the gatekeeper mutant T315I, is a significant problem for patients with chronicContinue Reading
  • B. Douglas Smith, Cynthia B. Leary, +7 authors Daniel L. Flynn
  • Medicine
  • 2013 (First Published: 15 December 2013)
  • In cancer models, TIE2 kinase plays an important role in angiogenesis, vasculogenesis, and tumor metastasis. TIE2 expression is largely restricted to vascular endothelial cells, tissue macrophages,Continue Reading