Scott C Mateer

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IQGAP1 colocalizes with actin filaments in the cell cortex and binds in vitro to F-actin and several signaling proteins, including calmodulin, Cdc42, Rac1, and beta-catenin. It is thought that the F-actin binding activity of IQGAP1 is regulated by its reversible association with these signaling molecules, but the mechanisms have remained obscure. Here we(More)
IQGAP1 is a homodimeric protein that reversibly associates with F-actin, calmodulin, activated Cdc42 and Rac1, CLIP-170, beta-catenin, and E-cadherin. Its F-actin binding site includes a calponin homology domain (CHD) located near the N-terminal of each subunit. Prior studies have implied that medium- to high-affinity F-actin binding (5-50 microM K(d))(More)
SV40 small tumor antigen (small-t) was used as a model to identify structural elements involved in the interactions between regulatory proteins and protein phosphatase 2A (PP2A). Using mutant proteins and synthetic peptides, we identified a small domain within small-t that is a major site for interaction with the dimeric form of PP2A. A series of small-t(More)
Cell motility and morphogenesis are the end products of highly coordinated cellular activities involving cytoskeletal structures, the machinery for cell adhesion, and signaling networks. Among the hundreds of proteins that contribute to cellular movements and shape changes, only a few lie at the hub of these activities by virtue of interacting directly with(More)
Current cutting-edge biomedical investigation requires that the researcher have an operational understanding of several diverse disciplines. Biocatalysis is a field of science that operates at the crossroads of organic chemistry, biochemistry, microbiology, and molecular biology, and provides an excellent model for interdisciplinary research. We have(More)
OBJECTIVE To determine whether two self-adhesive resin cements, Clearfil SA and RelyX, can be used to successfully bond orthodontic brackets to enamel. MATERIALS AND METHODS Seventy extracted premolars were custom mounted, cleaned and randomly divided into three groups. In group 1 (control), orthodontic brackets were bonded to 25 premolars using the(More)
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