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MOTIVATION Researchers need general purpose methods for objectively evaluating the accuracy of single and metagenome assemblies and for automatically detecting any errors they may contain. Current methods do not fully meet this need because they require a reference, only consider one of the many aspects of assembly quality or lack statistical justification,(More)
We consider parallel global optimization of derivative-free expensive-to-evaluate functions, and proposes an efficient method based on stochastic approximation for implementing a conceptual Bayesian optimization algorithm proposed by [10]. To accomplish this, we use infinitessimal perturbation analysis (IPA) to construct a stochastic gradient estimator and(More)
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