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genetic factors underlying common disease are largely unknown. Discovery of disease-causing genes will transform our knowledge of the genetic contribution to human disease, lead to new genetic screens, and underpin research into new cures and improved lifestyles. The se-quencing of the human genome has catalyzed efforts to search for disease genes by the(More)
Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that directly target HIV-1 capsid (CA) via a(More)
What is so unique about using the World Wide Web'? Or, is there anything unique about web use? This panel is designed to explore-though not necessarily answer-the question " is the web really different from everything else? " Keywords World Wide Web, User Experience, Design TOPIC The World Wide Web continues to attract attention and dollars unlike any new(More)
Processing of the Gag precursor protein by the viral protease during particle release triggers virion maturation, an essential step in the virus replication cycle. The first-in-class HIV-1 maturation inhibitor dimethylsuccinyl betulinic acid [PA-457 or bevirimat (BVM)] blocks HIV-1 maturation by inhibiting the cleavage of the capsid-spacer peptide 1(More)
The interaction between an imposed shear flow and an order--disorder transition underlies a broad range of phenomena. Under the influence of shear flow, a variety of soft matter is observed to spontaneously form bands characterized by different local order---for example, thermotropic liquid crystals subjected to shear flow exhibit rich phase behaviour. The(More)
a r t i c l e i n f o Brachiopods are long-lived, long-ranging, extant organisms, of which some groups precipitate a relatively diagenetically stable low magnesium calcite shell. Previous work has suggested that the incorporation of Mg into brachiopod calcite may be controlled by temperature (Brand et al., 2013). Here we build upon this work by using laser(More)
Adverse metabolic phenotype of female offspring exposed to preeclampsia in utero: a characterization of the BPH/5 mouse in postnatal life. (PE) is a devastating disorder of pregnancy that classically presents with maternal hypertension and proteinuria after 20 wk of gestation. In addition to being a leading cause of maternal and fetal morbidity/mortality,(More)
Progressive multifocal leukoencephalopathy (PML) is a rare but serious demyelinating disease of the brain that can result in severe disability or death. PML is caused by infection of oli-godendrocytes by the neuropathogenic form of JC polyoma-virus (JCV). There is a high prevalence of chronic but asymp-tomatic JCV infection in the general population.(More)
The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified mRNA LNPs encoding prM-E genes that produced virus-like(More)
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