Scott Brittain

Learn More
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent covalent MAGL inhibitor, SAR127303. The compound behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice. In vivo,(More)
This paper describes a method for fabricating three-dimensional (3D) microstructures with complex topologiesstrefoil, figure eight, and cinquefoil knots, a chain with complex links, Borromean rings, a Möbius strip, and a torus. This method is based on the strategy of decomposing these structures into figures that can be printed on the surfaces of cylinders(More)
  • 1