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Cyanobacteria are abundant throughout most of the world's water bodies and contribute significantly to global primary productivity through oxygenic photosynthesis. This reaction is catalysed by two membrane-bound protein complexes, photosystem I (PSI) and photosystem II (PSII), which both contain chlorophyll-binding subunits functioning as an internal(More)
To Our families Contents Foreword xi Preface xiii 1 Statistical approaches for clinical trials 1 1.1 Introduction 1 1.2 Comparisons between Bayesian and frequentist approaches 4 1.3 Adaptivity in clinical trials 6 1.4 Features and use of the Bayesian adaptive approach 8 1.4.1 The fully Bayesian approach 8 1.4.2 Bayes as a frequentist tool 10 1.4.3 Examples(More)
OBJECTIVE To compare response and remission rates in depressed patients with chronic treatment-resistant depression (TRD) treated with vagus nerve stimulation (VNS) Therapy(®) plus treatment as usual (VNS + TAU) or TAU alone in a meta-analysis using Bayesian hierarchical models. DATA SOURCES AND STUDY SELECTION Six outpatient, multicenter, clinical trials(More)
DISCLAIMER All statements in this report, including its findings and conclusions, are solely those of the authors and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute (PCORI), its Board of Governors or Methodology Committee. PCORI has not peer-reviewed or edited this content, which was developed through a contract(More)
The drug development enterprise is struggling. The development of new therapies is limited by high costs, slow progress, and a high failure rate, even in the late stages of development. Clinical trials are most commonly based on a " one population, one drug, one disease " strategy, in which the clinical trial infrastructure is created to test a single(More)
Inheritance of gene expression states is fundamental for cells to 'remember' past events, such as environmental or developmental cues. The conserved Polycomb Repressive Complex 2 (PRC2) maintains epigenetic repression of many genes in animals and plants and modifies chromatin at its targets. Histones modified by PRC2 can be inherited through cell division.(More)
Dulaglutide (dula, LY2189265) is a once-weekly glucagon-like peptide-1 analog in development for the treatment of type 2 diabetes mellitus. An adaptive, dose-finding, inferentially seamless phase 2/3 study was designed to support the development of this novel diabetes therapeutic. The study is divided into two stages based on two randomization schemes: a(More)
The Public Affairs Department of the American Statistical Association (ASA) maintains a database of members with expertise and experience in fields of statistical application who have volunteered to serve as sources of information for the media. The individuals on the list speak as experts in their fields, not as ASA spokespersons. While we have provided a(More)
The time is right for the use of Bayesian Adaptive Designs (BAD) in comparative effectiveness trials. For example, Patient Centered Outcomes Research Institute has joined the Food and Drug Administration and National Intitutes of Health in adopting policies/guidelines encouraging their use. There are multiple aspects to BAD that need to be considered when(More)
BACKGROUND Fluticasone furoate (FF)/vilanterol (VI) 100/25 mcg is a once-daily inhaled corticosteroid (ICS)/long-acting beta2 agonist (LABA) treatment approved in the United States, Canada and Europe for the long-term maintenance therapy of COPD. We report data from mixed treatment comparisons (MTC) of once-daily FF/VI against established twice-daily(More)