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Multiple comparisons and other multiplicities are among the most difficult of problems that face statisticians, frequentists, and Bayesians alike. An example is the analysis of the many types of adverse events (AEs) that are recorded in drug clinical trials. We propose a three-level hierarchical mixed model. The most basic level is type of AE. The second(More)
In the presence of covariate measurement error, estimating a regression function nonparametrically is extremely diicult, the problem being related to deconvolution. Various frequentist approaches exist for this problem, but to date there has been no Bayesian treatment. In this paper we describe Bayesian approaches to modeling a ex-ible regression function(More)
Cyanobacteria are abundant throughout most of the world's water bodies and contribute significantly to global primary productivity through oxygenic photosynthesis. This reaction is catalysed by two membrane-bound protein complexes, photosystem I (PSI) and photosystem II (PSII), which both contain chlorophyll-binding subunits functioning as an internal(More)
CONTEXT Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation (AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been proposed as an alternative treatment for paroxysmal AF. OBJECTIVE To determine the efficacy of catheter ablation compared with antiarrhythmic drug therapy (ADT) in(More)
To Our families Contents Foreword xi Preface xiii 1 Statistical approaches for clinical trials 1 1.1 Introduction 1 1.2 Comparisons between Bayesian and frequentist approaches 4 1.3 Adaptivity in clinical trials 6 1.4 Features and use of the Bayesian adaptive approach 8 1.4.1 The fully Bayesian approach 8 1.4.2 Bayes as a frequentist tool 10 1.4.3 Examples(More)
PURPOSE An accurate, intraoperative sentinel lymph node (SLN) test could decrease delayed axillary dissections. Molecular tests may be more sensitive than current intraoperative tests but historically have not been rapid enough and have not been properly validated. We present the results from a large, prospective evaluation of the first rapid molecular SLN(More)
In recent years, imaging based, automated, non-invasive, and non-destructive high-throughput plant phenotyping platforms have become popular tools for plant biology, underpinning the field of plant phenomics. Such platforms acquire and record large amounts of raw data that must be accurately and robustly calibrated, reconstructed, and analysed, requiring(More)
Tiger Woods has an amazing record of winning golf tournaments. He has gained the persona of a player that is a winner, a player that when near the lead or in the lead can do whatever it takes to win. In this paper I investigate whether in fact, he is a winner. A mathematical model is created for the ability of Tiger Woods, and all PGA Tour golfers to play(More)
RATIONALE Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle. OBJECTIVES To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic despite treatment with high-dose inhaled corticosteroids and(More)