Scott A. Snyder

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OBJECTIVE To investigate financial capacity in patients with Alzheimer disease (AD) using a new theoretical model and prototype psychometric instrument. DESIGN Cross-sectional comparisons of older control subjects (n=23) and patients with mild (n=30) and moderate AD (n=20). MAIN OUTCOME MEASURES Financial capacity was measured using the Financial(More)
BACKGROUND Sustained benefits of drug-eluting stents in femoropopliteal arteries have not been demonstrated. This prospective, multinational, randomized study was designed to compare the 12-month safety and effectiveness of a polymer-free, paclitaxel-coated nitinol drug-eluting stent (DES) with percutaneous transluminal angioplasty (PTA) and provisional(More)
In order to compare the cardiovascular and energy expenditure demands of "Super Slow" (SST) and traditional (TT) resistance training 7 resistance-trained young men (24.3 +/- 3.8 years) had energy expenditure (using indirect calorimetry) and heart rate evaluated during and for 15 minutes after a workout on separate days. Blood lactate levels were also(More)
Deep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus for essential tremor is sometimes limited by side effects. The mechanisms by which DBS alleviates tremor or causes side effects are unclear; thus, it is difficult to select stimulus parameters that maximize the width of the therapeutic window. The goal of this study was to(More)
Gap junctions provide direct intercellular communication by linking adjacent cells with aqueous pores permeable to molecules up to 1 kDa in molecular mass and 8-14 A in diameter. The identification of over a dozen connexins in the mammalian gap junction family has stimulated interest in the functional significance of this diversity, including the(More)
PURPOSE This trial evaluated the safety and effectiveness of thoracic endovascular aortic repair (TEVAR) with a contemporary endograft system compared with open surgical repair (open) of descending thoracic aortic aneurysms and large ulcers. METHODS Forty-two international trial sites enrolled 230 subjects with descending thoracic aortic aneurysms or(More)
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold(More)
OBJECTIVES To investigate financial capacity in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a clinician interview approach. DESIGN Cross-sectional. SETTING Tertiary care medical center. PARTICIPANTS Healthy older adults (n=75) and patients with amnestic MCI (n=58), mild AD (n=97), and moderate AD (n=31). (More)
OBJECTIVES A prospective, multinational randomized controlled trial (RCT) and a complementary single-arm study evaluated the 2-year safety and effectiveness of a paclitaxel-coated drug-eluting stent (DES) in patients with superficial femoral artery lesions. The RCT compared the DES with percutaneous transluminal angioplasty (PTA) and provisional bare-metal(More)
OBJECTIVE The purpose of this study was to determine the relationship between aneurysm sac size change at 1, 6, 12, and 24 months and a set of 10 independent "predictive" variables by using a general linear model analysis. METHODS In a multicenter trial, 351 patients received the Zenith tri-modular bifurcated endograft. The predictive variables used for(More)