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Studies of SOCS-1-deficient mice have implicated Socs-1 in the suppression of JAK-STAT (Janus tyrosine kinase-signal transducers and activators of transcription) signaling and T cell development. It has been suggested that the levels of Socs-1 protein may be regulated through the proteasome pathway. Here we show that Socs-1 interacts with members of the Pim(More)
The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely(More)
The pim family of proto-oncogenes encodes three serine-threonine kinases that have been implicated in the development of malignancies in mice and in humans. Expression of the Pim protein kinases is tightly regulated at the transcriptional, post-transcriptional, and translational levels. Dysregulation of pim transcription and pim mRNA stability have been(More)
Markets for electronic goods provide the possibility of exploring new and more complex pricing schemes, due to the flexibility of information goods and negligible marginal cost. In this paper we compare dynamic performance across price schedules of varying complexity. We provide a monopolist producer with two machine learning methods which implement a(More)
This paper offers a model of journal pricing that incorporates the portfolio demand behavior of libraries. The model is used to analyze four market regimes that differ with respect to the ability or inability of publishers to (1) price discriminate among customers and (2) bundle their journals. One of these regimes – no bundling or price discrimination –(More)
While the creation of a virtual store eliminates many of the costs incurred by the traditional bricks and mortar retailer, the spatial separation between customers and the retailer's distribution facility may result in significant distribution costs. In these circumstances, the determination of shipping and handling fee schedules becomes a key element of(More)
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