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In an effort to understand what integrative tasks are performed in the cochlear nuclei, the present study was undertaken to describe neuronal circuits in the posteroventral cochlear nucleus (PVCN) anatomically and physiologically. The cochlear nuclear complex receives auditory information from the cochlea through the auditory nerve. Within the cochlear(More)
Nissl-stained tissue from brain slice preparations of the anteroventral cochlear nucleus of the mouse resembles tissue fixed in situ. Multipolar, spherical, globular, and granule cells can be distinguished after intracellular injection with horseradish peroxidase (HRP). Stellate cells have relatively large dendritic fields; their axons have collaterals(More)
Intracellular recordings from brain slice preparations of the ventral cochlear nuclei (VCN) of mice have shown that both the major cell types, stellate and bushy cells, distinguishable by their responses to intracellularly injected current (Oertel, 1983; Wu and Oertel, 1984), receive late inhibitory as well as early excitatory inputs when the auditory nerve(More)
Auditory nerve fibers carry impulses from the cochlea to the cochlear nuclei. There the temporal firing patterns of auditory nerve fibers are preserved by some cells and altered by others. The two factors which govern how firing patterns are shaped are (1) the intrinsic electrical properties of cells that determine the size and time course of voltage(More)
BETA2/NeuroD1 is a basic helix-loop-helix transcription factor that is expressed widely throughout the developing nervous system. Previous studies have shown that BETA2/NeuroD1 influences the fate of retinal cells in culture. To analyze the effect of BETA2/NeuroD1 on the structure and function of the retina, we examined a line of BETA2/NeuroD1 knock-out(More)
Horseradish peroxidase (HRP) was injected into cells from which intracellular recordings were made in slices of the dorsal cochlear nucleus (DCN) in order to correlate physiology with morphology. In general, the morphology of cells labeled intracellularly with HRP corresponded to those made with Golgi impregnations in mice and other mammals. The following(More)
The ventral nucleus of the lateral lemniscus (VNLL) is a prominent neuronal group that lies within the auditory pathway connecting the auditory lower brainstem and midbrain. Previous physiologic studies showed that VNLL neurons respond mainly to contralaterally presented sounds and display various firing patterns. To understand better the role that VNLL(More)
PURPOSE To characterize changes in fluorophore metabolism during acute idiopathic maculopathy (AIM) using autofluorescence (AF) imaging. METHODS AF imaging was performed during the clinical course of a 38-year-old man with AIM. RESULTS AF imaging initially revealed distinct hypofluorescence corresponding to a clinical pattern of retinal pigment(More)