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  • Budhaditya Mukherjee, Rupkatha Mukhopadhyay, +8 authors Syamal Roy
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2013 (First Publication: 12 February 2013)
  • The molecular mechanism of antimony-resistant Leishmania donovani (Sb(R)LD)-driven up-regulation of IL-10 and multidrug-resistant protein 1 (MDR1) in infected macrophages (Ms) has been investigated.Continue Reading
  • Joydeep Paul, Kshudiram Naskar, Sayan Roy Chowdhury, Tapati Chakraborti, Tripti De
  • Biology, Medicine
  • Biochimie
  • 2014 (First Publication: 1 December 2014)
  • During Leishmania donovani (LD) infection Interleukin (IL)-10 favors parasite replication and plays a central role as a target for immune-based therapy. Glycogen synthase kinase 3 (GSK3)βContinue Reading
  • Sayan Roy Chowdhury, Rupkatha Mukhopadhyay, +4 authors Hemanta K Majumder
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2014 (First Publication: 4 April 2014)
  • Background: Leishmania donovani adopts several defense mechanisms to become resistant to antileishmanial agents. Results: Laboratory-grown flavone (baicalein)-resistant parasites exhibit efflux ofContinue Reading
  • Sayan Roy Chowdhury, Tulika Mukherjee, Souvik Sengupta, Somenath Roy Chowdhury, Sibabrata Mukhopadhyay, Hemanta K Majumder
  • Biology, Medicine
  • Molecular pharmacology
  • 2011 (First Publication: 1 October 2011)
  • Toward developing antileishmanial agents with mode of action targeted to DNA topoisomerases of Leishmania donovani, we have synthesized a large number of derivatives of betulin. The compound, aContinue Reading
  • Sayan Roy Chowdhury, Tulika Mukherjee, +4 authors Hemanta K Majumder
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 2014 (First Publication: 1 April 2014)
  • The unicellular organism Leishmania undergoes apoptosis-like cell death in response to external stress or exposure to antileishmanial agents. Here, we showed that 3-O,28-O-disuccinyl betulin (DiSB),Continue Reading
  • Tulika Mukherjee, Sayan Roy Chowdhury, Ashish Kumar, Hemanta K Majumder, Parasuraman Jaisankar, Sibabrata Mukhopadhyay
  • Biology, Medicine
  • Natural product communications
  • 2012 (First Publication: 1 June 2012)
  • Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3,Continue Reading
  • Joydeep Paul, Kshudiram Naskar, Sayan Roy Chowdhury, Md. Nur Alam, Tapati Chakraborti, Tripti De
  • Biology, Medicine
  • Indian journal of biochemistry & biophysics
  • 2014 (First Publication: 1 December 2014)
  • In visceral leishmaniasis, a fragmentary IL-12 driven type 1 immune response along with the expansion of IL-10 producing T-cells correlates with parasite burden and pathogenesis. SuccessfulContinue Reading
  • Sourav Saha, Tulika Mukherjee, +5 authors Hemanta K Majumder
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2013 (First Publication: 1 December 2013)
  • Lignans are diphenyl propanoids with vast range of biological activities. The present study provides an important insight into the anti-leishmanial activities of two lignan glycosides, viz. lyonisideContinue Reading