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Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the… Expand
An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
- Sayan Chakraborty, M. Lakshmanan, +9 authors W. Hong
- Medicine, Biology
- Nature communications
- 29 January 2015
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. The identity and role of cell surface molecules driving complex biological events leading to HCC… Expand
Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
In addition to the structural and scaffolding role, the extracellular matrix (ECM) is emerging as a hub for biomechanical signal transduction that is frequently relayed to intracellular sensors to… Expand
A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.
Endothelial cell (EC) recruitment is central to the vascularization of tumors. Although several proteoglycans have been implicated in cancer and angiogenesis, their roles in EC recruitment and… Expand
Abstract 5036: Elucidating an oncogenic role of an extracellular matrix protein, Agrin, in hepatocellular carcinoma
Reactive Oxygen Species (ROS) are Induced by Kaposi's
Oncogenetic engagement with mechanosensing
Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now… Expand
Agrin Mediates Angiogenesis in the Tumor Microenvironment.
Angiogenesis represents a hallmark of cancer. Several proteoglycans associate with cell surface receptors and regulate angiogenesis within the tumor microenvironment (TME). We highlight the recent… Expand
UTX and MBD3 Epistasis Regulates Rac Gtpase Activation and Sensitizes Human Acute Myeloid Leukemia Cells to Dock Inhibition
Kaposi’s Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells
- Mohanan Valiya Veettil, G. Krishna, +7 authors B. Chandran
- Biology, Medicine
- Journal of Virology
- 22 January 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) manipulates several cellular pathways for its survival advantage during its latency in the infected human host. Here, we demonstrate that KSHV infection… Expand