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Both Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils have putative anti-agitation properties in humans, indicating common components with a depressant action in the central nervous system. A dual radioligand binding and electrophysiological study, focusing on a range of ligand-gated ion channels, was performed with a chemically(More)
A dual radioligand binding and electrophysiological study, focusing on a range of ligand-gated ion channels, was performed with a chemically-validated essential oil derived from Melissa officinalis (MO), which has shown clinical benefit in treating agitation. MO inhibited binding of [35S] t-butylbicyclophosphorothionate (TBPS) to the rat forebrain(More)
OBJECTIVES The Jordanian 'Melissa', (Aloysia citrodora) has been poorly studied both pharmacologically and in the clinic. Essential oils (EO) derived from leaves of A. citrodora were obtained by hydrodistillation, analysed by gas chromatography-mass spectrometry (GC-MS) and were investigated for a range of neurobiological and pharmacological properties, as(More)
Xiaohui Chang (changxiaohui323@163.com) Lina Liang (lianglina304@sohu.com) Libin Zhan (libinzhan2013@163.com) Xiaoguang Lu (dllxg@yahoo.com.cn) Xiang Shi (shixiang1318@hotmail.com) Xin Qi (qixindl@163.com) Zhaolan Feng (xydida@yahoo.com) Meijuan Wu (wmj820502@sohu.com) Hua Sui (dianasuihua@163.com) Luping Zheng (zzllpp311@163.com) Fulaing Zhang(More)
Caloporoside is a natural active fungal metabolite, which was isolated from Caloporous dichrous and was described to exhibit antibacterial, antifungal and phospholipase C inhibitory activity. We have previously reported evidence that related beta-linked compounds, lactose and octyl-beta-d-mannoside, bind and functionally modulate rodent GABA(A) receptors,(More)
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