Saurabh Singh

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RNA interference (RNAi) strategies include double-stranded RNA (dsRNA), small interfering RNA (siRNA), short hairpin RNA (shRNA), and microRNA (miRNA). As this is a highly specific technique, efforts have been made to utilize RNAi towards potential knock down of disease-causing genes in a targeted fashion. RNAi has the potential to selectively inhibit gene(More)
Abstract— Wireless sensor network is highly vulnerable to attacks because it consists of various resourceconstrained devices with their low battery power, less memory, and associated low energy. Sensor nodes communicate among themselves via wireless links. However, there are still a lot of unresolved issues in wireless sensor networks of which security is(More)
Type-2 diabetes mellitus (DM-2) is a conformational disease involving intrinsically disordered islet amyloid polypeptide (IAPP), in which a structural transition from physiological polypeptide to pathological deposits takes place. Different factors acquired or inherited, contribute to endoplasmic reticulum stress and/or impair mitochondrial function which(More)
Hedgehog (Hh) and epidermal growth factor receptor (EGFR) signaling are involved in pancreatic cancer progression. Targeting these pathways simultaneously with cyclopamine (Hh inhibitor) and gefitinib (EGFR inhibitor) is a promising approach for treating pancreatic cancer. However, the major limitation for effective clinical translation of these molecules(More)
Pancreatic cancers relapse due to small but distinct population of cancer stem cells (CSCs) which are in turn regulated by miRNAs. The present study identifies a series of miRNAs which were either upregulated (e.g. miR-146) or downregulated (e.g. miRNA-205, miRNA-7) in gemcitabine resistant MIA PaCa-2 cancer cells and clinical metastatic pancreatic cancer(More)
Ligand-induced conformational changes are of immense importance for the biological activity of a protein. An in-depth understanding of salutary and deleterious effects of ligand-induced conformational alterations in single- and multi-chain proteins would lend a hand in human welfare. Unlike single-chain proteins, the function of multichain proteins depends(More)
In this paper, we proposed a hash based approach for color image steganography using canny edge detection method. One of the advantages of using edge detection technique is to secure our data. Proposed methodology follows encoding and decoding procedure. For encoding the data in an image we follow a steganography procedure. Steganography is the art of(More)
The growing demand for an independent and comfortable lifestyle has motivated the development of the smart home, and providing security is a major challenge for developers and security analysts. Enhancing security in the home environment has been recognized as one of the main obstacles to realizing the vision of creating energy-efficient smart homes and(More)