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Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ causes insulin sensitization(More)
Twitter, used in 200 countries with over 250 million tweets a day, is a rich source of local news from around the world. Many events of local importance are first reported on Twitter, including many that never reach news channels. Further, there are often only a few tweets reporting each such event, in contrast with the larger volumes that follow events of(More)
We seek to extend the scope and efficiency of iterative compilation techniques by searching not only for program transformation parameters but for the most appropriate transformations themselves. For that purpose, we need to find a generic way to express program transformations and compositions of transformations. In this article, we introduce a framework(More)
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic and inflammatory rheumatic disease that leads to inflammation of the joints and surrounding tissues. Identification of novel protein(s) associated with severity of RA is a prerequisite for better understanding of pathogenesis of this disease that may also have potential to serve as novel(More)
This paper presents a new architecture model, named Weld, for VLIW processors. Weld integrates multithreading support into a VLIW processor to hide run-time latency effects that cannot be determined by the compiler. It does this through a novel hardware technique called operation welding that merges operations from different threads to utilize the hardware(More)
Rheumatoid arthritis (RA) is a chronic, autoimmune and inflammatory joint disease with a poorly understood etiology. Despite widespread diagnostic use of anti-citrullinated protein antibodies and rheumatoid factor proteins there is a strong demand for novel serological biomarkers to improve the diagnosis this disease. The present study was aimed to identify(More)
Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases. A 69-year-old male developed progressively increasing(More)
Effective data prefetching requires accurate mechanisms to predict embedded patterns in the miss reference behavior. This paper proposes a novel prefetching mechanism, called the spectral prefetcher (SP), that accurately identifies the pattern by dynamically adjusting to its frequency. The proposed mechanism divides the memory address space into tag(More)
BACKGROUND Extra-adrenal pheochromocytomas are rare. Minimally invasive techniques have been utilized for incidentally discovered masses with successful results. METHODS We present a case of a 64-year-old female with a 3.5-cm mass located between her left renal artery and vein, treated by a 4-port robot-assisted transperitoneal laparoscopic approach. (More)
Neuropathic pain triggers a cascade of events in the sensory neurons. It is the main complication of diabetes after cardiovascular disease. Nitric oxide (NO) produced from nitric oxide synthases (NOS) is an important signaling molecule which is crucial for many physiological processes such as synaptic plasticity, neuronal survival, vasodilation, vascular(More)