Sauli Savolainen

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OBJECTIVES Transcranial magnetic stimulation (TMS) and high-resolution electroencephalography (EEG) were used to study the spreading of cortical activation in 6 healthy volunteers. METHODS Five locations in the left sensorimotor cortex (within 3cm(2)) were stimulated magnetically, while EEG was recorded with 60 scalp electrodes. A frameless stereotactic(More)
Four different postprocessing methods to determine cerebral blood volume (CBV) and contrast agent mean transit time (MTT) by dynamic susceptibility contrast (DSC) MRI were compared. CBV was determined by two different methods that integrate tracer concentration-time curves numerically and by two other methods that take recirculation into account. For the(More)
We present a contextual clustering procedure for statistical parametric maps (SPM) calculated from time varying three-dimensional images. The algorithm can be used for the detection of neural activations from functional magnetic resonance images (fMRI). An important characteristic of SPM is that the intensity distribution of background (nonactive area) is(More)
Two clinical trials are currently running at the Finnish dedicated boron neutron capture therapy (BNCT) facility. Between May 1999 and December 2001, 18 patients with supratentorial glioblastoma were treated with boronophenylalanine (BPA)-based BNCT within a context of a prospective clinical trial (protocol P-01). All patients underwent prior surgery, but(More)
UNLABELLED BACKGROUND Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, wild-type healthy mice were scanned(More)
OBJECT To evaluate functional magnetic resonance imaging (fMRI) and simultaneous electroencephalography (EEG)-fMRI data quality in an organization using several magnetic resonance imaging (MRI) systems. MATERIALS AND METHODS Functional magnetic resonance imaging measurements were carried out twice with a uniform gel phantom on five different MRI systems(More)
former Beamline Responsible, ID17, for allowing me to use the outstanding working facilities of their institutions. Physicist of the Department of Oncology, for proposing to me the topic of this study and guiding me throughout this research work. Professor Suortti introduced me to the physics of X-ray diffraction; without the benefit of his world-renowned(More)
A new technique for visualization of interventional devices in magnetic resonance imaging is presented. Determination of the position of an invasive device is made possible by incorporating into the device a small marker that emits the NMR signal. This signal is enhanced by the use of the Overhauser phenomenon. This technique differs from the earlier(More)
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