Saul J Karpen

Learn More
BACKGROUND: Lipopolysaccharide (LPS) treatment of animals down-regulates the expression of hepatic genes involved in a broad variety of physiological processes, collectively known as the negative hepatic acute phase response (APR). Retinoid X receptor alpha (RXRalpha), the most highly expressed RXR isoform in liver, plays a central role in regulating bile(More)
PREAMBLE These recommendations provide a data-supported approach to establishing guidelines. They are based on the following: (1) a formal review and analysis of recently published world literature on the topic (via a PubMed/MEDLINE search from 1996 to July 2011 limited to the English language, human studies, and children 0-18 years old); (2) A Manual for(More)
  • 1