Sau Yan Chan

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miR-203 is a tumour suppressor microRNA (miRNA). We studied the methylation of hsa-miR-203 in 150 samples including acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML), chronic lymphocytic leukaemia (CLL) and non-Hodgkin's lymphoma (NHL) by methylation-specific PCR, and miRNA expression by stem-loop RT-qPCR.(More)
Sixty patients with advanced breast cancer unresponsive to tamoxifen have been randomised to receive four course of mitozantrone, 14 mg m-2 (n = 30) intravenously every 3 weeks (9 weeks total) or megesterol acetate, 160 mg bd (n = 30). One in three patients (11 from each group) had substantial disease control for a minimum period of 6 months i.e., lack of(More)
A biochemical response index comprising ESR, CEA and CA 15.3 was evaluated in 67 patients with systemic breast cancer treated by chemotherapy; 55 were assessable by UICC criteria and the response index (96% of all UICC assessable patients). Marker changes at 2 and 4 months showed a highly significant correlation with the UICC assessed response at 3 and 6(More)
Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without(More)
The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in Hong Kong with that of Scotland and(More)
A VLDL-associated cytotoxic factor was isolated from sera of pregnant rats and characterized. The inhibitory effect of this factor on the macromolecular synthesis of rat prostate adenocarcinoma cells (PA-III) was also examined. VLDL (Sf 20-400) was subfractionated by differential ultracentrifugal flotation and the Sf 100-400 fraction was associated with(More)
There is now abundant evidence for the presence of large quantities of unseen matter surrounding normal galaxies, including our own 1,2. The nature of this 'dark matter' is unknown, except that it cannot be made of normal stars, dust, or gas, as they would be easily detected. Exotic particles such as axions, massive neutrinos or other weakly interacting(More)
A set of mouse nonoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with 131I and administered to 20 patients with different malignant diseases. Good tumour(More)
Both the androgen and glucocorticoid receptors of the Pollard prostate adenocarcinoma cell lines (PA-II and PA-III) have been examined and characterized. Both cell lines contains distinct binding sites for 5 alpha-dihydrotestosterone (DHT) and dexamethasone (DM). The specific binding of the ligands to the whole cell was saturable, and Scatchard analysis(More)
A chemically defined medium (MB-DF) has been developed for the propagation of the rat prostate adenocarcinoma cell line (PA-III). The medium (MB-DF) was supplemented with fetuin, insulin, transferrin, dexamethasone, and 5 alpha - dihydrotestosterone, but require no serum supplement. The adapted line, PA-IIIf, has been grown in this serum-free medium for 30(More)