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Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction--staged sentinel lymph nodes from melanoma patients.
With extended follow-up of patients with histologically negative SLNs, detection of submicroscopic disease by tyrosinase RT-PCR does not define a subgroup that is at higher recurrence risk when compared with patients with RT- PCR-negative SLNs. Expand
Colorectal liver metastases.
This review focuses on preoperative evaluation, surgical planning and the role of adjuvant therapies in the management of patients with colorectal liver metastases. Expand
Real-World Implementation of Video Outpatient Consultations at Macro, Meso, and Micro Levels: Mixed-Method Study
Video outpatient consultations appear safe, effective, and convenient for patients in situations where participating clinicians judge them clinically appropriate, but such situations are a fraction of the overall clinic workload. Expand
Inflammatory and Immune Responses to Surgery and Their Clinical Impact
Improved understanding of these mechanisms has implications for clinical study design and has led to the emergence of novel biomarkers such as Toll-like receptor expression that can be used to stratify patient care pathways to maximize the benefit from current therapies or to select the right target at the right phase of illness for future drug development. Expand
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes
The reciprocal relationship of E‐cadherin and polymeric immunoglobulin receptor (PIGR) expression in cancer cells could be shown, in vivo, to be dependent on the stromal content of human pancreatic cancer, demonstrating that context‐specific cancer–stroma crosstalk requires to be precisely defined for effective therapeutic targeting. Expand
Locating the stem cell niche and tracing hepatocyte lineages in human liver
Data show, for the first time, that clonal proliferative units exist in the human liver, an origin from a periportal niche is most likely, and that the trajectory of the units is compatible with a migration of cells from the perip Mortal regions to the hepatic veins. Expand
Detection of Tyrosinase mRNA by Reverse Transcription Polymerase Chain Reaction in Melanoma Sentinel Nodes
Among patients undergoing SLN biopsy, tyrosinase mRNA was detectable in 73% of SLNs from patients at risk for regional nodal metastases, including all of those with histologically positive SLNs, and there is a definable false-positive rate for tyros inase mRNA detection in the lymph nodes of patients who do not have melanoma. Expand
Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial
Summary Background The interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction in progression-free survival inExpand
Advantages and limitations of virtual online consultations in a NHS acute trust: the VOCAL mixed-methods study
Background There is much enthusiasm from clinicians, industry and the government to utilise digital technologies and introduce alternatives to face-to-face consultations. Objective(s) To define goodExpand
A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues
The results suggest that the stem cell niche is located at the base of colonic crypts and above the Paneth cell region in the small intestine, in accord with dynamic cell kinetic studies in animals. Expand