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The Metabolic Rate Constants and Specific Activity of Human and Rat Hepatic Cytochrome P-450 2E1 Toward Toluene and Chloroform
- J. Lipscomb, H. Barton, +4 authors J. Laskey
- Chemistry, Medicine
- Journal of toxicology and environmental health…
- 1 April 2004
Chloroform (CHCl3) is a near-ubiquitous environmental contaminant, a by-product of the disinfection of drinking water sources and a commercially important compound. Standards for safe exposure have… Expand
Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes.
- M. Santostefano, V. Richardson, +5 authors L. Birnbaum
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 November 1999
Dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest a differential sensitivity of liver cell types to the induction of cytochrome P450 gene expression, and that the… Expand