Satoshi Yoshida

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AIMS/INTRODUCTION In the present dose-response study, we evaluated the efficacy and safety of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose cotransporter 2, in Japanese patients with type 2 diabetes mellitus. MATERIALS AND METHODS A total of 361 patients from 39 Japanese centers were randomized to receive either(More)
AIMS/INTRODUCTION The influence of overweight/obesity on the clinical efficacy and safety of sodium-glucose co-transporter 2 inhibitors is unclear. We carried out a pooled analysis to examine the impact of body mass index on the efficacy and safety of ipragliflozin. MATERIALS AND METHODS Patient-level data were pooled for five Japanese double-blind trials(More)
In this paper, we propose a simple method for direct access to variable-to-fixed length codes (VF codes) by adding an auxiliary succinct index structure to the encoded text. The method solves the substring decompression problem in O(N/n+l) time in the average case, where N, n, and l are the original text length, the encoded text length, and the length of(More)
Almost Instantaneous VF code proposed by Yamamoto and Yokoo in 2001, which is one of the variable-length-to-fixed-length codes, uses a set of parse trees and achieves a good compression ratio. However, it needs much time and space for both encoding and decoding than an ordinary VF code does. In this paper, we proved that we can multiplex the set of parse(More)
This paper discusses pattern matching on Variable-to-Fixed-length codes (VF codes). A VF code is a coding scheme whose codeword lengths are fixed, and thus it is suitable for comprssed pattern matching. However, there are few reports showing its efficiency so far. We present some experimental results about the compression ratios and encoding/decoding speeds(More)
AIMS/INTRODUCTION To determine the efficacy and safety of ipragliflozin in combination with metformin in Asian patients with type 2 diabetes mellitus. MATERIALS AND METHODS This phase 3, multicenter, placebo-controlled, double-blind, parallel-group study was carried out at 18 sites in Korea and 12 sites in Taiwan. After an 8-week washout period for(More)
AIMS Ipragliflozin is a novel and highly selective sodium-glucose transporter 2 (SGLT2) inhibitor that reduces plasma glucose levels by enhancing urinary glucose excretion in patients with type 2 diabetes mellitus (T2DM). We examined the pharmacokinetic and pharmacodynamic characteristics of two oral doses of ipragliflozin in Japanese patients with T2DM. (More)
Summary form only given. We address the problem of improving variable-length-to-fixed-length codes (VF codes). A VF code is an encoding scheme that uses a fixed-length code, and thus, one can easily access the compressed data. However, conventional VF codes usually have an inferior compression ratio to that of variable-length codes. Although a method(More)
The Re-Pair algorithm proposed by Larsson and Moffat in 1999 is a simple grammar-based compression method that achieves an extremely high compression ratio. However, Re-Pair is an offline and very space consuming algorithm. Thus, to apply it to a very large text, we need to divide the text into smaller blocks. Consequently, if we share a part of the(More)