Satoshi Ushiro

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As a heat load prediction method in district cooling and heating systems, the efficiency of a layered neural network has been shown, but there is a drawback that its prediction becomes less accurate in periods when the heat load is non-stationary. In this paper, we propose a new heat load prediction method superior to existing methods by using a recurrent(More)
In this paper, for general multiobjective 0-1 programming problems involving positive and negative coefficients, considering fuzzy goals to represent the ambiguous nature of the decision maker's judgment for objective functions, we propose a fuzzy satisficing method through genetic algorithms which is an extension of genetic algorithms with double strings(More)
Epidermal growth factor (EGF) or transforming growth factor-alpha (TGF-alpha) stimulates cell migration, proliferation and the formation of tube-like structures of human microvascular endothelial cells in culture. Heparin-binding EGF-like growth factor(HB-EGF), which shows 35% homology with EGF/TGF-alpha, is a member of the EGF family, and it is ubiquitous(More)
Our previous studies imply that tumor necrosis factor-alpha (TNF-alpha) and epidermal growth factor (EGF) might share a common signal transduction pathway in human omental microvascular endothelial (HOME) cells. Exposure of cultured HOME cells to TNF-alpha for 10 min enhanced EGF receptor phosphorylation at a rate comparable to EGF. Apparent phosphorylation(More)
District heating and cooling (DHC) systems have been actively introduced as energy supply systems in urban areas. Since there exist a number of large-size freezers, heat exchangers and boilers in a DHC plant to generate and supply cold water, hot water and steam to a DHC system, the control under an operation plan for these instruments on the basis of the(More)
To investigate if neurotensin (NT) could induce activation of urokinase-type plasminogen activator (uPA) in vascular endothelial cells, we utilized the acetyl-NT (8-13) analogue, TJN-950, in which the C-terminal leucine is reduced to leucinol. TJN-950 inhibited the binding of 125I-NT to membranes of newborn rat brains and of COS-7 cells transfected with rat(More)
Human omental microvascular endothelial (HOME) cells seeded on Matrigel begin to migrate within 1 h, forming honeycomb-like structures and capillary-like networks within 18 h. Cross-sections of the capillary networks show them to be tube-like structures. Northern blot analysis showed that tissue-type plasminogen activator (t-PA) mRNA synthesis increased(More)
Irsogladine used clinically as an anti-gastric ulcer agent, at 10(-6)-10(-4)M, inhibited cell proliferation and tubular morphogenesis of vascular endothelial cells, but the proliferation of human epidermoid cancer or glioma cells was not inhibited by this drug, even at 10(-4)M. In vivo studies demonstrated that p.o. administration of irsogladine(More)