Satoshi Tsuji

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Bayesian learning has been widely used and proved to be effective in many data modeling problems. However, computations involved in it require huge costs and generally cannot be performed exactly. The variational Bayesian approach, proposed as an approximation of Bayesian learning, has provided computational tractability and good generalization performance(More)
The mechanism of slow muscarinic excitation in bullfrog sympathetic ganglia was studied using a single-electrode voltage clamp technique. The membrane current induced by muscarine (0.01-30 microM: Imus) consisted of a voltage-dependent component (dIM) induced by the inhibition of K+-current (known as IM), a voltage-independent cation-selective current (ID),(More)
Multineuronal recordings have enabled us to examine context-dependent changes in the relationship between the activities of multiple cells. The joint peri-stimulus time histogram (JPSTH) is a much-used method for investigating the dynamics of the interdependence of spike events between pairs of cells. Its results are often taken as an estimate of(More)
Glutamate-mediated excitotoxicity, mainly induced by N-methyl-d-aspartate (NMDA) receptors, is known to cause retinal ganglion cell death in retinal ischemia, glaucoma, and several other retinal diseases. We evaluated the effects of β-estradiol (E2) against a single intravitreal injection of NMDA using a functional and morphological approach. Male rats were(More)
1 ABSTRACT Multineuronal recordings have enabled us to examine context-dependent changes in the relationship between the activities of multiple cells. The Joint Peri-Stimulus Time Histogram (JPSTH) is a much-used method for investigating the dynamics of the interdependence of spike events between pairs of cells. Its results are often taken as an estimate of(More)
In bullfrog sympathetic ganglion cells, muscarine produced an inward current (Imus) through the activation of a subtype (M1) of muscarinic acetylcholine receptor (mAChR) by suppressing an outward M-current (IM), and/or activating cation-selective current (ID; see below). The former was induced with a potency (Kd = 0.5 microM) higher than the latter (Kd = 5(More)
The 'ionic fixation' of soluble quaternary ammonium compounds such as choline and acetylcholine by phosphomolybdic acid was used to fix [3H]choline taken up in the frog motor nerve terminal. The rapid 'ionic fixation' allowed autoradiography of [3H]choline directly at the electron microscopic level without considerable diffusion artifacts. Most of the(More)