Satoshi Takano

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This paper proposes a new speech modification algorithm based on a vocoder framework to synthesize high quality speech. Its innovation is in preserving the fine structure of the magnitude spectrum. A key point is the use of a " compensatory gaussian window " to extract moderate F 0 harmonics structures in the magnitude spectrum. The other key point is,(More)
Cyclic ADP-ribose (cADPR, 1, Scheme 1), originally isolated from sea urchins by Lee and co-workers, [1] is a general mediator of intracellular Ca 2+ ion signaling. [2] Analogues of cADPR have been extensively designed and synthesized [3, 4] because of their potential usefulness for investigating the mechanisms of cADPR-mediated Ca 2+ release and application(More)
In the adult heart of the isopod crustacean Ligia exotica, the cardiac ganglion acts as the primary pacemaker with the myocardium having a latent pacemaker property. We show several lines of evidence that dopamine modulates the heartbeat of adult L. exotica affecting both pacemaker sites in the heart. Dopamine caused positive chronotropic (frequency(More)
Here we describe the successful synthesis of cyclic ADP-4-thioribose (cADPtR, 3), designed as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger, in which the key N1-β-thioribosyladenosine structure was stereoselectively constructed by condensation between the imidazole nucleoside derivative 8 and the 4-thioribosylamine 7(More)
This paper describes a new Japanese text-to-speech (TTS) system that can produce highly natural and intelligible synthetic speech. The good performance of the new TTS system derives from three new sophisticated approaches as follows; (1)A new prosody control algorithm that uses prosody data extracted from a natural speech database and a duration control(More)
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