Satoshi Takano

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This paper proposes a new speech modification algorithm based on a vocoder framework to synthesize high quality speech. Its innovation is in preserving the fine structure of the magnitude spectrum. A key point is the use of a “compensatory gaussian window” to extract moderate F0 harmonics structures in the magnitude spectrum. The other key point is,(More)
Here we describe the successful synthesis of cyclic ADP-4-thioribose (cADPtR, 3), designed as a stable mimic of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger, in which the key N1-β-thioribosyladenosine structure was stereoselectively constructed by condensation between the imidazole nucleoside derivative 8 and the 4-thioribosylamine 7 via(More)
Cyclic ADP-carbocyclic-ribose (cADPcR, 3) is a biologically and chemically stable equivalent of cyclic ADP-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger. We became interested in the biological activity of the 7-deaza analogues of cADPcR, i.e., 7-deaza-cADPcR (7) and its 7-bromo derivative, i.e., 7-deaza-7-Br-cADPcR (8), because 7-deazaadenosine is(More)
In recent years, the performance of cellphone cameras has improved, and is becoming comparable to that of SLR cameras. However, the big difference between cellphone cameras and SLR cameras is the distortion due to the rolling exposure of CMOS image sensors (CISs) because cellphone cameras cannot have a mechanical shutters [1]. In addition to this technical(More)
We established a preparation method of brush-on-brush copolymers by grafting from photoinduced ATRP of multifunctional polystyrene having N,N-diethyldithiocarbamate (DC) pendant groups with stearyl methacrylate (STM). We studied the solution properties of brush-on-brush copolymers from the view point of crowding effect of PSTM brush side chains. It was(More)
This paper describes a new Japanese text-to-speech (TTS) system that can produce highly natural and intelligible synthetic speech. The good performance of the new TTS system derives from three new sophisticated approaches as follows; (1)A new prosody control algorithm that uses prosody data extracted from a natural speech database and a duration control(More)
because of their potential usefulness for investigating the mechanisms of cADPR-mediated Ca release and application as lead structures for the development of drug candidates. cADPR is very unstable and can be hydrolyzed not only by cADPR hydrolase in cells but also in neutral aqueous solution at the labile N1-ribosyl linkage. We previously synthesized(More)
Cyclic adenosine diphosphate-carbocyclic-ribose (cADPcR, 2) is a stable equivalent of cyclic adenosine diphosphate-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger. On the basis of the structure-activity relationship of cADPR-related compounds and three-dimensional structural modeling of cADPcR, we designed and synthesized cyclic-ADP-4″α-azidoethyl(More)