Satoshi Nunomura

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The b-chain of the high-affinity receptor for IgE (FceRI) plays a crucial role for amplification of the intracellular signaling in mast cells upon FceRI cross-linking by IgEantigen complexes (IgEAg). Some monomeric IgE as well as IgEAg stimulate FceRI-signaling pathways, leading to cell activation, whereas the biological functions of the b-chain in the(More)
BACKGROUND Myelitis is one of the rarest neurological complications of the varicella zoster virus (VZV) infection. Focal muscle weakness with or without sensory disturbance occurs in approximately 5% of the cases after acute VZV infection, with complete recovery in 50-70%. CASE PRESENTATION This report describes two rare cases of elderly patients with VZV(More)
Mast cells play a key role in allergic reaction and disorders through the high affinity receptor for IgE (Fc(ε)RI) which is primarily activated by IgE and antigen complex. In humans, mast cells express two types of Fc(ε)RI on the cell surface, tetrameric αβγ(2) and trimeric αγ(2), whereas in mice, the tetrameric αβγ(2) type is exclusively expressed. In(More)
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