Satoshi Hayakawa

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PROBLEM To examine whether natural killer (NKT) cells are present in human pregnancy decidua. METHOD OF STUDY We calculated the percentage of CD3+CD161+Valpha 24+-NKT cells in peripheral blood and early pregnancy decidua, and analyzed intracellular cytokines, interleukin (IL)-4 and interferon (IFN)gamma in NKT cells using flow cytometry. RESULTS A(More)
OBJECTIVE To investigate the clinical outcome, ECG characteristics, and optimal treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), a malignant and rare ventricular tachycardia. PATIENTS AND METHODS Questionnaire responses and ECGs of 29 patients with CPVT were evaluated. Mean (SD) age of onset was 10.3 (6.1) years. RESULTS The(More)
PROBLEM The mechanism of immunotherapy for patients with recurrent spontaneous abortions is not well understood. In order to investigate the suppressor mechanism of paternal lymphocyte immunization, we examined peripheral blood lymphocyte subpopulations and the repertoire of T-cell receptor (TCR) gene segments. METHOD OF STUDY Twelve patients with(More)
PROBLEM Human endometrial glands contain the highest levels of cyclooxygenase (COX), although whether it is COX-1 and/or COX-2 has not been previously determined. Overexpression of COX-2 may result in the pathogenesis of endometriosis. METHOD OF STUDY Tissue sections were obtained from 28 premenopausal women undergoing laparotomy or laparoscopic surgery(More)
OBJECTIVE To explain the correlation between HLA class II genes and the intractability of ulcerative colitis (UC), DR genotyping and clinical analysis were performed for patients with UC. METHODS HLA-DRB types and HLA-DR2 subtypes of 45 patients with UC in our hospital were determined using molecular genotyping in combination with sequence-specific(More)
PROBLEM Chemokine receptors of placental trophoblasts possibly act as co-receptors or alternative receptors of maternal fetal infection by HIV. To clarify their possible expression and the physiological roles of chemokines on human placentae, we studied chemokine chemokine receptor expression and the effects of exogenous chemokines on choriocarcinoma cell(More)
An amorphous titania gel layer was formed on the titanium surface after the titanium specimen was treated with a H2O2/0.1 M HCl solution at 80 degrees C. The thickness of the gel layer increased almost linearly with the period of the treatment. A subsequent heat treatment above 300 degrees C transformed gradually the amorphous gel to the anatase crystal(More)
In late 2012, an outbreak of acute gastroenteritis due to norovirus variant Sydney_2012 occurred and have been reported from many counties. In this study, we described surveillance study of the incidence of norovirus infections among Japanese pediatric patients in association with gastroenteritis and investigated the antigenic change of the new variant(More)
Commercially available pure metallic titanium was chemically treated at 60 degrees C for 24 h with H2O2 solutions containing various metal chlorides to provide titanium with bioactivity, that is, to give it the ability to form a biologically active bone-like apatite layer on the surface. After the chemical treatment the titanium specimens were soaked in a(More)
Several catechin compounds were examined for their ability to induce apoptosis in human histiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3-O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These(More)