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Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

• Keisuke Kohga, Tomohide Tatsumi, +14 authors Tetsuo Takehara
• Cancer Immunology, Immunotherapy
• 2012

The production of soluble major histocompatibility complex class I–related chain A (MICA) is thought to antagonize NKG2D-mediated immunosurveillance. Interleukin-1β (IL-1β) is elevated in patients… (More)

CD14+ monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C.

• Akira Nishio, Tomohide Tatsumi, +12 authors Tetsuo Takehara
• Hepatology
• 2017

Natural killer (NK) cell activation is associated with both liver injury and persistent infection in chronic hepatitis C (CHC); however, the detailed mechanism of this activation has not yet been… (More)

The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice.

• Hiroshi Aketa, Tomohide Tatsumi, +14 authors Tetsuo Takehara
• International journal of cancer
• 2013

α-Galactosylceramide (α-GalCer) has been reported to be therapeutic against metastatic liver tumors in mice. However, little is known regarding the efficacy of combined chemo-immunotherapy using… (More)

Tu1472 Bcl-xL Overexpression Promotes Pancreatic Ductal Adenocarcinoma Through the Inhibition of Cellular Senescence Induced by KRAS Mutation

• Kenji Ikezawa, Minoru Shigekawa, +8 authors Tetsuo Takehara
• 2016

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice.

• Satoshi Aono, Tomohide Tatsumi, +12 authors Tetsuo Takehara
• Biochemical and biophysical research…
• 2018

It is well known that immune-mediated virus elimination is necessary for the treatment of HBV infection. Reconstitution of human immune cells in liver chimeric mice is warranted to understand the… (More)

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