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The mIMCD-3 cell line, developed from simian virus 40 transformed mice, was grown on coverslips for single-channel analysis of the apical membrane. An amiloride-sensitive nonselective cation channel (NCATP) was demonstrated that occurred predominantly in excised patches. The selectivity sequence for NCATP was NH4+ = Na+ = K+ = Li+ = Rb+ > Cl-. The(More)
~" and r/chains of the T cell antigen receptor (TCR) complex and the y chain of Fc receptors (FcRy) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In ~'-deficient mice, TCR expression was reduced in most T cells. By contrast, CD8oto~ + TCR-~//5 + intestinal(More)
The inner medullary collecting duct (IMCD) in vivo has the capacity to either secrete or reabsorb K+. However, a selective K+ conductance has not been described previously in the IMCD. In the present study, the patch-clamp method was used to determine the presence and properties of K(+)-selective channels in the apical membrane of the inner medullary(More)
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