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Asymmetric synthesis by enantiomer-selective activation of racemic catalysts
Asymmetric catalysis of organic reactions to provide enantiomerically enriched products is of central importance to modern synthetic and pharmaceutical chemistry1–3. While non-racemic catalysts can… Expand
Enantioselective and diastereoselective catalysis of the Mukaiyama aldol reaction: ene mechanism in titanium-catalyzed aldol reactions of silyl enol ethers
Enantiomer-selective activation of racemic catalysts.
- K. Mikami, M. Terada, T. Korenaga, Y. Matsumoto, Satoru Matsukawa
- Chemistry, Medicine
- Accounts of chemical research
- 20 June 2000
Asymmetric catalysts can be evolved into highly activated catalysts by association with chiral activators. This asymmetric activation process is particularly useful in racemic catalysis through… Expand
Samarium(II)-mediated pinacol coupling in water: occurrence of unexpected disproportionation and action of low-valent samarium as an active species.
[reaction: see text] Mechanistic studies of one-electron reduction in water using samarium were carried out. Unexpected disproportionation in water was observed via UV-vis spectroscopic analysis.… Expand
Distribution of herpes simplex virus types 1 and 2 genomes in human spinal ganglia studied by PCR and in situ hybridization
Clinical data indicate that the recurring herpes simplex virus (HSV) from oro‐labial lesions is HSV subtype 1 and that the virus from genital lesions is HSV‐2. This suggests that HSV‐1 and HSV‐2… Expand
Highly selective one-pot synthesis of spirophosphoranes exhibiting reversed apicophilicity by oxidation of dianions generated from P-H spirophosphorane.
- K. Kajiyama, M. Yoshimune, M. Nakamoto, Satoru Matsukawa, S. Kojima, K. Akiba
- Chemistry, Medicine
- Organic letters
- 18 May 2001
[see reaction]. Mild and highly selective one-pot procedures for obtaining phosphoranes that exhibit reversed (O-cis) apicophilicity are described. On the basis of the procedures, O-cis phosphorane… Expand
TTMPP-catalyzed trifluoromethylation of carbonyl compounds and imines with trifluoromethylsilane
A highly basic phosphine, tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP), catalyzes trifluoromethylation using trifluoromethyltrimethylsilane to give the corresponding trifluoromethylated products in… Expand
Importance of chiral activators in the asymmetric catalysis of Diels-Alder reactions by chiral titanium(IV) complexes
Abstract Asymmetric activation of chiral titanium(IV) complexes is found to be essential to provide higher levels of enantioselectivity than that attained by enantiopure catalysts in Diels-Alder… Expand
Regioselective allylation reactions using crotyl Grignard reagent–CeCl3 systems
Abstract Regioselective allylation reactions using crotyl Grignard reagent–CeCl 3 systems are described. Regioselectivity depends on the lanthanide salts: α-product was predominantly produced with… Expand
TTMPP: An efficient organocatalyst in the ring-opening of aziridines with silylated nucleophiles.
The ring-opening of N-tosylaziridines with silylated nucleophiles catalyzed by tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP) afforded the corresponding beta-functionalized sulfonamides in excellent… Expand