Satomi Niwayama

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Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases. Fumagillin and ovalicin compose a class of structurally related natural products that potently inhibit angiogenesis by blocking endothelial cell proliferation. A synthetic analog of fumagillin, TNP-470, is currently undergoing clinical(More)
We investigated the internalization and growth of influenza A NWS virus in macrophagelike P388D1 cells. Flow cytometric analysis using fluorescein isothiocyanate-labeled virus showed that the attachment of normal rabbit serum-exposed virus (NS-V) to neuraminidase (NA)-treated cells was noticeably limited compared with that to untreated cells. However,(More)
A new methodology for quantitative analysis of proteins is described, applying stable-isotope labeling by small organic molecules combined with one- or two-dimensional electrophoresis and MALDI-TOF-MS, also allowing concurrent protein identification by peptide mass fingerprinting. Our method eliminates fundamental problems in other existing isotope-tagging(More)
13C-Labeled and unlabeled iodoacetanilides have been synthesized for covalent modification of the sulfhydryl groups of cysteine residues in proteins or peptides. A combination of these reagents, coupled with mass spectrometry, is a powerful tool for quantitative analysis of peptides and hence proteins.
The growth of influenza virus A/PR/8/34 in MDCK cells was inhibited by 1-(5-isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride (H7) which is a potent inhibitor of protein kinase C, but not by an effective inhibitor of cyclic nucleotide-dependent protein kinases. Analysing the inhibitory effect of H7 during the replication cycle of influenza virus, we(More)
Perfluorination of phthalimides leads to dramatically increased potency as inhibitors of TNF-alpha production. We examined the enantiodependence for several tetrafluorophthalimides and alpha-methylthalidomide, 3. Only 3 exhibited strikingly enantiodependent activity. The key structural determinant for the enhanced activity is the tetrafluorophthaloyl group,(More)
In the course of our search for new antibiotics produced by Streptomyces sp., a water-soluble antibiotic, effective against gram-negative bacteria, was obtained from the nitrate of a culture broth of Streptomyces No. 5879 isolated from a soil sample collected in Aizu area (Fukushima prefecture). Antibiotic No. 5879 appears to be a novel one from its(More)
A 45-year-old male who had looked over pet-birds at a bird shop 11 days before, developed a high fever with chills. Without any response to cephalexin, he was admitted to the hospital, with the chief complaints of high fever and sever headache on the 8th day of illness. The chest X-ray films taken then revealed a fun-shaped ground glass-like shadow(More)
  • S Miyamura, N Ogasawara, H Otsuka, S Niwayama, H Tanaka
  • 1973
In the previous paper1}, we presented a preliminary report on a new water-soluble antibiotic 5879 produced by Streptomyces No. 5879. Differences in the taxonomic properties of the strain from those of recognized species were considered to be significant enough to propose the new species Streptomyces aizunensis nov. sp. for this strain, and antibiotic 5879(More)