Thromboxane A2 (TXA2) is a central prostanoid in the cardiovascular system and is a crucial mediator of vascular homeostasis and platelet aggregation. In this study, we report a novel role for TXA2 in neurite outgrowth. TXA2 receptor is expressed in rat cortical neurons, and treatment with the TXA2 agonist U-46619 promotes neurite outgrowth in a… (More)
The interaction of neurons with their non-neuronal milieu plays a crucial role in the formation of neural networks, and wide variety of cell-contact-dependent signals that promote neurite elongation have been identified. In this study, we found that vascular endothelial cells promote neurite elongation in an integrin β3-dependent manner. Vascular… (More)
Left hemiparesis exhibited during the post-eruptive stage of exanthem subitum (ES) in an 11-month-old girl. Tc-99m HMPAO brain SPECT showed diffuse hypoperfusion in right hemisphere. Hemiparesis has occasionally been reported as central nervous system (CNS) complications of ES, and Tc-99m HMPAO brain SPECT was useful for evaluating of CNS involvement.