Satish Y. Gabhe

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Kumariasava is a marketed ayurvedic formulation containing Aloe vera as one of the main ingredients. Present study aims to standardize Kumariasava based upon chromatographic and spectral studies. Various extracts of Kumariasava have been prepared and evaluated. Chloroform extract indicated presence of three well-resolved fluorescent components. Spectral(More)
The present work exploits the potential of in silico approaches for minimizing attrition of leads in the later stages of drug development. We propose a theoretical approach, wherein 'parallel' information is generated to simultaneously optimize the pharmacokinetics (PK) and pharmacodynamics (PD) of lead candidates. β-blockers, though in use for many years,(More)
A reversed phase high performance liquid chromatography coupled with diode array detector (HPLC–DAD) was developed and validated to quantitate diosgenin in berries of Solanum nigrum using C18 analytical column as stationary phase and acetonitrile: water (92: 08, v/v) as mobile phase. The flow rate of mobile phase was kept at 1.0 ml/min. Column oven(More)
The aqueous extract of the aerial roots the Indian Banyan, Ficus benghalensis L. (Family: Moraceae) was evaluated for its effect on both specific and non-specific immunity. This extract exhibited a significant increase in percentage phagocytosis by human neutrophils in the in vitro tests. It exhibited promising immunostimulant activity at doses of 50, 100,(More)
The Indian Banyan is a large tree, bearing many aerial roots. An aqueous decoction of the fresh aerial roots of this tree has been used by traditional ayurvedic medical practitioners to boost the immune system in various diseases. In AIDS, death occurs eventually due to the failing immune system hence new therapies directed towards augmenting the functional(More)
Azadirachta indica has been used for its medicinal properties since time immemorial. Herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. No reports are available for marker-based standardization of these herbal medicines prepared from leaves of A. indica. Also existing HPLC methods for(More)
Introduction: Rosa damascena mill L., well-known as Rose, has numerous pharmacological properties including antioxidant, antitussive, relaxant effect on tracheal chains, hypnotic, antibacterial and anti-HIV. Objective: The objective of the present study was to evaluate antioxidant and free radical scavenging activity of various extracts of Rose flower(More)
A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (impurity I),(More)
The antioxidant properties and the effect on nitric oxide (NO) production of various extracts of leaves of Anacardium occidentale were investigated. Radical-scavenging potential was evaluated using the 1,1-diphenyl-2picrylhydrazyl (DPPH) radical. Griess assay was used to assess NO-inhibitory activity of the extracts. The antioxidant activity of aqueous,(More)
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