Satish K. Chitneni

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UNLABELLED Phosphodiesterases are enzymes that inactivate the intracellular second messengers 3',5'-cyclic adenosine-monophosphate and/or cyclic guanosine-monophosphate. Of all 11 known phosphodiesterase families, phosphodiesterase-10A (PDE10A) has the most restricted distribution, with high expression in the striatum. PDE10A inhibitors are pursued as drugs(More)
INTRODUCTION Malignant gliomas frequently harbor mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Studies suggest that IDH mutation contributes to tumor pathogenesis through mechanisms that are mediated by the neomorphic metabolite of the mutant IDH1 enzyme, 2-hydroxyglutarate (2-HG). The aim of this work was to synthesize and evaluate radiolabeled(More)
Editorial Isocitrate dehydrogenases IDH1 and IDH2 are closely-related metabolic enzymes which catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) by oxidative decarboxylation and simultaneously generate NADPH in cells. IDH1 and IDH2 are frequently mutated in WHO grade II and grade III gliomas and in secondary glioblastoma. In gliomas, IDH(More)
INTRODUCTION Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. To accomplish this, we developed the residualizing radioiodination agent N(ϵ)-(3-[(*)I]iodobenzoyl)-Lys(5)-N(α)-maleimido-Gly(1)-D-GEEEK(More)
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