Satish K. Chitneni

Learn More
A wide variety of imaging approaches have been developed in the past few decades for monitoring tumor oxygenation and hypoxia in vivo. In particular, nuclear medicine has seen the development of several radiolabeled hypoxia markers and is the preferred method for imaging of tumor hypoxia. Hypoxia imaging is increasingly being used in the clinical setting(More)
UNLABELLED Phosphodiesterases are enzymes that inactivate the intracellular second messengers 3',5'-cyclic adenosine-monophosphate and/or cyclic guanosine-monophosphate. Of all 11 known phosphodiesterase families, phosphodiesterase-10A (PDE10A) has the most restricted distribution, with high expression in the striatum. PDE10A inhibitors are pursued as drugs(More)
INTRODUCTION Malignant gliomas frequently harbor mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Studies suggest that IDH mutation contributes to tumor pathogenesis through mechanisms that are mediated by the neomorphic metabolite of the mutant IDH1 enzyme, 2-hydroxyglutarate (2-HG). The aim of this work was to synthesize and evaluate radiolabeled(More)
Editorial Isocitrate dehydrogenases IDH1 and IDH2 are closely-related metabolic enzymes which catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) by oxidative decarboxylation and simultaneously generate NADPH in cells. IDH1 and IDH2 are frequently mutated in WHO grade II and grade III gliomas and in secondary glioblastoma. In gliomas, IDH(More)
  • 1