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BACKGROUND Penicillamine is a standard therapy for Wilson disease (WD) but some patients have paradoxical worsening. Predictors of such deterioration have not been evaluated. This study documents frequency and predictors of deterioration following treatment in WD. METHODS 59 consecutive patients with neurologic WD and 4 asymptomatic siblings were(More)
PURPOSE To report the frequency and predictors of presenting seizures in cerebral venous sinus thrombosis (CVST) and their influence on seizure recurrence and outcome. METHODS This retrospective study, between 1995 and 2011, included 90 consecutive patients with CVST diagnosed using magnetic resonance imaging (MRI) and magnetic resonance venography (MRV).(More)
OBJECTIVE To evaluate cognitive functions and behavioral changes in the patients with vitamin B12 deficiency neurological syndromes (VBDNS) using detailed clinical psychometric and P3 studies and their response to treatment. METHODS The patients with VBDNS were included and their detailed medical history was recorded. Neurobehavioral and cognitive(More)
OBJECTIVE The frequency and type of neuropathy in vitamin B12 deficiency neurological syndrome (VBDNS) is controversial. This study reports the frequency and type of nerve dysfunction in VBDNS using nerve conduction and sural nerve biopsy and its response to treatment. METHOD Sixty-six patients with VBDNS diagnosed on the basis of low serum vitamin B12(More)
The objective of this study is to evaluate clinical picture, radiological findings and response to treatment in patients with antibiotic associated status epilepticus (SE). In a retrospective review, 12 out of 117 (10%) patients with SE had temporal association with antibiotic administration. Their medical history, clinical findings, and duration and type(More)
This is the era of Infopreneurs and web researchers for finding the best fit decisions. For general advice or recommendation, the information need arises. The advice should be such, that best fits the situational need, context and is feasible to afford. Research talks variedly about recommendation systems and expert finding systems for expert advice. These(More)
The present study demonstrates the application and usefulness of concept of travel time reliability on Indian roads. Travel time data collected on an urban arterial in New Delhi during morning and evening peak periods are analyzed and various reliability and congestion measures are evaluated. Attempt is also made to correlate reliability measures such as(More)
Opsoclonus myoclonus syndrome is a rare paraneoplastic syndrome seen in 50% of children with neuroblastoma. Neural generator of opsoclonus and myoclonus is not known but evidences suggest the role of fastigial nucleus disinhibition from the loss of function of inhibitory (GABAergic) Purkinje cells in the cerebellum. We present a child with paraneoplastic(More)