Sathish Paramasivan

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BACKGROUND The relationship between sinonasal nitric oxide (NO) levels and the pathogenic organism Staphylococcus aureus is yet to be established. High NO levels measured in healthy sinuses likely contribute to maintenance of relative sterility. Lower concentrations such as is found in the sinuses of chronic rhinosinusitis (CRS) patients may decrease this(More)
The burden of drug resistance emerges in the wake of chronic and repeated antibiotic use. This underpins the importance of discovering alternatives to current antibiotic regimens. In chronic rhinosinusitis (CRS), topical therapy such as nasal douches and steroid sprays is the mainstay of treatment. However, bacterial sinusitis such as those with(More)
OBJECTIVES/HYPOTHESIS Biofilms are associated with clinical relapse following surgery for chronic rhinosinusitis. Encased bacteria are protected from innate immunity and antimicrobial therapy. Surfactants can disperse the biofilm into its planktonic phenotype so that traditional treatments may be effective. The aim of this study was to assess a surfactant(More)
BACKGROUND Bacterial biofilms are thought to contribute to recalcitrance in chronic rhinosinusitis (CRS) patients. Manuka honey (MH) and its active component methylglyoxal (MGO) have demonstrated antibiofilm activity in vitro. This study evaluated the safety and efficacy of these agents in an in vivo model. METHODS To assess safety, ovine frontal sinuses(More)
The histological study was carried out on mammary glands collected from 14 Madras red sheep, 7 in lactating period 7 in non-lactation period. The connective tissue became reduced and lobuloalveolar tissue was predominantly increased during lactating period. The alveoli were laminated, filled with secretion and lined by cuboidal active secretory cells(More)
BACKGROUND Bacteriophage (phage) therapy has been proposed as an alternative to antibiotics. Phages have been shown to kill antibiotic resistant Staphylococcus aureus strains; however, it is unknown whether stress-induced antibiotic tolerance affects S. aureus susceptibility to phages. Our objective was to determine the effectiveness of 2 phages currently(More)
BACKGROUND The most dreaded hemorrhagic complication in endoscopic endonasal surgery is injury to the internal carotid artery (ICA). Although a number of treatment protocols are currently used, none have been formally investigated. This study aims to compare the efficacy of the muscle patch, bipolar diathermy, and aneurysm clip on hemostasis, pseudoaneurysm(More)
Parathyroid glands from laying hens were also  xed in percent glutaraldehyde in phosphate buffer (0.1 M, 7.3 pH) for araldite embedding and used for electron microscopy. For routine histological observations, sections of 5 to 6 um thickness were cut and stained by, Mayer’s haemalum and eosin-phloxine, Masson’s trichrome, Crossman’s modi cation of(More)
BACKGROUND Chitosan-dextran gel has been used as an antihemostatic agent and antiadhesive agent after endoscopic sinus surgery. Because Staphylococcus aureus biofilms have been implicated in recalcitrant chronic rhinosinusitis, this study aimed to further investigate the (i) anti-inflammatory, (ii) bacterial biofilm inhibition, (iii) antiproliferative(More)
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