Sathanur R. Srinivasan

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BACKGROUND In adults, cardiovascular risk factors reinforce each other in their effect on cardiovascular events. However, information is scant on the relation of multiple risk factors to the extent of asymptomatic atherosclerosis in young people. METHODS We performed autopsies on 204 young persons 2 to 39 years of age, who had died from various causes,(More)
OBJECTIVE To derive optimal body mass index (BMI) and waist circumference thresholds for children and adolescents, to predict risk factor clustering. DESIGN Cross-sectional receiver operating characteristic curve analysis. SETTING The Bogalusa Heart Study, a community-based study of cardiovascular disease risk factors in early life. PARTICIPANTS A(More)
BACKGROUND Although overweight and obesity in childhood are related to dyslipidemia, hyperinsulinemia, and hypertension, most studies have examined levels of these risk factors individually or have used internal cutpoints (eg, quintiles) to classify overweight and risk factors. OBJECTIVE We used cutpoints derived from several national studies to examine(More)
BACKGROUND Childhood obesity is related to adult levels of lipids, lipoproteins, blood pressure, and insulin and to morbidity from coronary heart disease (CHD). However, the importance of the age at which obesity develops in these associations remains uncertain. OBJECTIVE AND DESIGN We assessed the longitudinal relationship of childhood body mass index(More)
BACKGROUND Several investigators have concluded that the waist-to-height ratio is more strongly associated with cardiovascular disease risk factors than is the body mass index (BMI; in kg/m(2)). OBJECTIVES We examined the relation of the BMI-for-age z score and waist-to-height ratio to risk factors (lipids, fasting insulin, and blood pressures). We also(More)
Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell replication, ultimately leads to replicative senescence. In humans, rare mutations in genes that regulate telomere length have been identified in monogenic diseases such as dyskeratosis congenita and(More)
CONTEXT Carotid artery intima-media thickness (IMT) is associated with cardiovascular risk factors and is recognized as an important predictive measure of clinical coronary atherosclerosis events in middle-aged and elderly populations. However, information on the association of carotid IMT in young adults with different risk factors measured in childhood,(More)
OBJECTIVE To explore the accuracy of various body mass index (BMI) cutpoints in identifying children who have excess adiposity (based on skinfold thicknesses), adverse levels of lipids, insulin, and blood pressures, and a high risk for severe adult obesity. STUDY DESIGN Cross-sectional (n = 10,099) and longitudinal (n = 2392) analyses were performed among(More)
BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided(More)
BACKGROUND Leukocyte telomere length (LTL) is considered a biomarker of human aging and based on cross-sectional studies it shortens with age. However, longitudinal studies reported that many adults display LTL lengthening. METHODS Using Southern blots, we compared cross-sectional rates of age-related LTL change across a ∼20 year age range with those(More)