Sasidharan Balukrishna

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PURPOSE Detecting circulating plasma tumor DNA (ptDNA) in patients with early-stage cancer has the potential to change how oncologists recommend systemic therapies for solid tumors after surgery. Droplet digital polymerase chain reaction (ddPCR) is a novel sensitive and specific platform for mutation detection. EXPERIMENTAL DESIGN In this prospective(More)
Carcinoma of the esophagus is known to metastasize to lung, liver, bone, and brain. Metastasis to soft tissue, though rare, has been reported from adenocarcinoma of the esophagus. Interestingly, squamous cell carcinoma of esophagus has not been reported to metastasize to the subcutaneous tissue. We present a patient with squamous cell carcinoma of esophagus(More)
Among various altered fractionation schedules, only hyper-fractionation has proven increased local control in head and neck cancers. MARCH (Metanalyses of Hyperfractionated or Accelerated radiotherapy in Head and neck cancer) concluded that hyper-fractionated radiotherapy in head and cancers had a survival benefit. This study attempts to combine the(More)
Digital polymerase chain reaction is a new technology that enables detection and quantification of cancer DNA molecules from peripheral blood. Using this technique, we identified mutant PIK3CA DNA in circulating ptDNA (plasma tumor DNA) from a patient with concurrent early stage breast cancer and non-small cell lung cancer. The patient underwent successful(More)
The prospective use for MV CT for patient treatment planning are for consecutive phase plans in 3D conformal and intensity modulated radiotherapy, patients with metal implants, adaptive radiation therapy and single fraction palliative treatment. This study is to validate the authors' previous work on MV cone beam CT (MV CBCT) images reconstructed with(More)
In areas like adaptive therapy, multi-phase radiotherapy, and single fraction palliative treatment or in the treatment of patients with metal implants where megavoltage(MV) CT could be considered as a treatment planning modality, the reduced contrast in the MV CT images could lead to limited accuracy in localization of the structures. This would affect the(More)
Purpose: Detecting circulating plasma tumor DNA (ptDNA) in patients with early-stage cancer has the potential to change how oncologists recommend systemic therapies for solid tumors after surgery. Droplet digital polymerase chain reaction (ddPCR) is a novel sensitive and specific platform formutation detection. Experimental Design: In this prospective(More)
Glioblastoma Multiforme (GBM) is a high-grade brain tumour with the most dismal prognosis. There are very few reports on second malignancies occurring in GBM patients, as the survival has been short. Second malignancies have been reported after treatment of malignancies with radiation therapy and chemotherapy especially after 5 to 10 y of treatment. Here(More)
AIM The purpose of the survey was to understand the role of positron emission tomography (PET) in clinical radiotherapy practice among the radiation oncologists' in India. SETTINGS AND DESIGN An online questionnaire was developed to survey the oncologists on their use of PET, viewing protocols, contouring techniques practiced, the barriers on the use of(More)
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