Sasha Nikolaeva

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This study applied an experimental rat model and ceramic as an artificial matrix to explore the ultrastructural development of new bone production in tibia defects. By X-ray diffraction control or energy-dispersive X-ray analysis the nature of ceramic was verified and routine histology and TEM investigation were used to demonstrate bone - ceramic(More)
The stability of collagen molecules and moisture capacity of human normal and osteoarthrotic (OA) cartilage were studied before and after extraction of glycosaminoglycans (GAG) by 4M guanidinum chloride. The content and nature of water were determined by Fisher titration, DSC and analysis of sorbtion-desorbtion processes of water vapour in cartilage. The(More)
Determination of the content and state of water bound in medicinal phytopreparations is necessary for establishing a scientifically justified methodological approach to standardization of these substances and the regime of their drying, packaging, and storage. The accuracy and reliability of the evaluation methods can be significantly increased by using(More)
The natural agent deltostim is a mixture of furanostanol steroid glycosides characterized by a high anabolic and a low androgenic activities. In doses of 5–30 mg/kg it stimulates the production of proteins and nucleic acids in the skeletal and cardiac muscles. These doses do not suppress biopolymer production in the liver, which indicates that the agent is(More)
Alterations in physico-chemical properties and in content of several biochemical components were found in skin during postmortal storage of the tissue at the temperature 22 degrees and 5 degrees and relative moisture 92%. Within 96-120 hrs of the postmortal storage a decrease in content of hydrate-bound water and of glycosaminoglycans occurred in the(More)
The oral polybacterial immunomodulator Dentavax (D), composed of killed cells from Klebsiella pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Candida albicans and Lactobacillus acidophilus and their lysates was created for immunoprophylaxis and therapy of oral mucosa and parodont inflammations. The stimulating effect of the preparation was(More)
Methods of thermal analysis, including differential scanning calorimetry (DSC) and thermogravimetry (TG), increasingly are being applied in pharmaceutics for the evaluation and development of properties of medicinal phytopreparations and standard substances. The melting temperature and water content are among the most important parameters characterizing the(More)
The effect of ionizing radiation (gamma-irradiation of 60Co, doses from 10 Gy to 15 kGy) on human muscle tissue was studied using a biopsy material. Destructive alterations in muscle proteins were observed beginning from the dose of 1.0 kGy: appearance of new protein fractions with molecular mass 68-160 kDa and 18-36 kDa. Resistance of muscle proteins to(More)