Sascha Hilgenfeldt

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The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation of bubble-enhanced(More)
In multicellular organisms, cells pack together to form tissues of intricate and well defined morphology. How such cell-packing geometries arise is an important open question in biology, because the functionality of many differentiated tissues depends on their reliable formation. We show that combining adhesive forces due to E- and N-cadherin with a(More)
Microfluidics typically uses channels to transport small objects by actuation forces such as an applied pressure difference or thermocapillarity. We propose that acoustic streaming is an alternative means of directional transport at small scales. Microbubbles on a substrate establish well controlled fluid motion on very small scales; combinations(More)
A new experimental method is presented using fluorescein dye to determine the spatial and temporal variations of the liquid volume fraction in aqueous foams. This method is used for quantitative studies of liquid redistribution (drainage) in three types of experiments: forced, free, and pulsed drainage. Characteristic quantities, such as the drainage(More)
The scattering of ultrasound from bubbles of ∼ 1 μm radius, such as used in contrast enhancers for ultrasound diagnostics, is studied. We show that sound scattering and “active” emission of sound from oscillating bubbles are not contradictory, but are just two different aspects derived from the same physics. Treating the bubble as a nonlinear oscillator, we(More)
The drainage of liquid through a foam involves flow in channels, also called Plateau borders, which generally are long and slender. We model this flow by assuming the flow is unidirectional, the shear is transverse to the flow direction, and the liquid/gas interfaces are mobile and characterized by a Newtonian surface viscosity, which does not depend on the(More)
In a confluent, single-cell tissue layer, we show that cell shapes and statistics correlate directly with the tissue's mechanical properties, described by an energy functional with generic interfacial terms only. Upon increasing the cohesive component of the model, we observe a clear transition from a tense state with isotropic cells to a relaxed state with(More)
We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This fast coalescence cannot be explained by dissipation-limited(More)