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Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
This corrects the article DOI: 10.1038/nature13038
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The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment
Understanding how differentiation programs originate from the gene-expression 'landscape' of hematopoietic stem cells (HSCs) is crucial for the development of new clinical therapies. We mapped theExpand
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Identification of pre-leukemic hematopoietic stem cells in acute leukemia
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typicallyExpand
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CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
Summary Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency,Expand
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Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants
A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome‐wide association study; this finding has been replicated in case–control studiesExpand
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Experimental evaluation of pathogenicity of Streptococcus iniae in Silver Shark and Rainbow Shark
7cfu of the bacteria after one week of acclimatization. Classical signs of streptococcosis appeared in some silver sharks in less than 10 h after bacterial challenge and the mortality was recorded 16Expand
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Aging, clonal hematopoiesis and preleukemia: not just bad luck?
Chronological human aging is associated with a number of changes in the hematopoietic system, occurring at many levels from stem to mature cells, and the marrow microenvironment as well. This reviewExpand
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DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia
Leukemia in humans arises from the multistep accumulation of mutations. However, the identity of the cell of origin, the nature of the first genetic lesion and the order of subsequent mutationsExpand
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The Road to Commitment: Lineage Restriction Events in Hematopoiesis
All the mature blood cells in circulation as well as in other tissues can be generated by one and the same hematopoietic stem cell. Upon cell division, the multipotent stem cell generates oneExpand
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A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency.
There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked toExpand
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