Sasa Dimitrijevic

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BACKGROUND Gastrointestinal stromal tumours (GISTs) are rare tumours of the gastrointestinal tract characterised by cell-surface expression of the tyrosine kinase KIT (CD117). No effective systemic treatment is available. Imatinib (STI571) inhibits a similar tyrosine kinase, BCR-ABL, leading to responses in chronic myeloid leukaemia, and has also been shown(More)
Previous studies have shown that activating mutations of c-KIT/PDGFRA, potential therapeutic targets for imatinib mesylate, are implicated in the pathophysiology of gastrointestinal stromal tumours (GISTs). In this study, GISTs from 37 patients enrolled in an European Organisation for Research and Treatment of Cancer (EORTC) phase I/II clinical study of(More)
Imatinib mesylate is a selective inhibitor of a few tyrosine kinases including KIT, and it is the first effective treatment for gastrointestinal stromal tumors (GISTs). We monitored the serum levels of KIT, KIT ligand (stem cell factor, SCF), and the vascular endothelial growth factor (VEGF) in patients with advanced GISTs treated with imatinib in a(More)
—The first commercially available teslameter with a fully integrated three-axis Hall probe is described. The Hall probe chip contains horizontal and vertical Hall elements, analog electronics , and a synchronization circuit. A horizontal Hall element measures the perpendicular component, and two vertical Hall devices measure the two in-plane components of a(More)
– The new digital teslameter system incorporates a 3-axis Hall probe, analog electronics based on the spinning-current technique, 24-bit analog-to-digital converter, computer, and 7-digit touch-screen display. The Hall probe is a single silicon chip with monolithically integrated horizontal and vertical Hall magnetic sensors and a temperature sensor. The(More)
Background: Non pigmented eccrine poroma is a benign tumor that can have dermoscopic features mimicking malign neoplasias. The characteristic vascular pattern of this tumor hasn't been established. We found a scarcely reported vas-cular pattern, which can be useful to distinguish this tumor from malignant ones and propose a new nomenclature to these vessels(More)
(1930 articles) Signal Transduction (795 articles) Oncogenes and Tumor Suppressors (4217 articles) Neoplasia (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: articles must include the digital object identifier(More)
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