Sasa Dimitrijevic

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Mutations of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human mastocytosis (SAHM) and with human gastrointestinal stromal tumors. We have classified KIT-activating mutations as either "enzymatic site" type (EST) mutations, affecting the structure of the catalytic portion of the kinase, or as(More)
Imatinib mesylate is a selective inhibitor of a few tyrosine kinases including KIT, and it is the first effective treatment for gastrointestinal stromal tumors (GISTs). We monitored the serum levels of KIT, KIT ligand (stem cell factor, SCF), and the vascular endothelial growth factor (VEGF) in patients with advanced GISTs treated with imatinib in a(More)
—The first commercially available teslameter with a fully integrated three-axis Hall probe is described. The Hall probe chip contains horizontal and vertical Hall elements, analog electronics , and a synchronization circuit. A horizontal Hall element measures the perpendicular component, and two vertical Hall devices measure the two in-plane components of a(More)
(1930 articles) Signal Transduction (795 articles) Oncogenes and Tumor Suppressors (4217 articles) Neoplasia (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: articles must include the digital object identifier(More)
– The new digital teslameter system incorporates a 3-axis Hall probe, analog electronics based on the spinning-current technique, 24-bit analog-to-digital converter, computer, and 7-digit touch-screen display. The Hall probe is a single silicon chip with monolithically integrated horizontal and vertical Hall magnetic sensors and a temperature sensor. The(More)
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