Ciliotherapy: a novel intervention in polycystic kidney disease
- Sarmed H. Kathem, Ashraf M. Mohieldin, S. Nauli
- Medicine, BiologyJournal of Geriatric Cardiology
- 1 March 2014
The studies provide the first evidence of ciliotherapy as an innovative intervention in patients with abnormal primary cilia, and indicated that cilia-targeting therapy showed an overall reduction in mean arterial pressure in PKD patients.
The Roles of Primary cilia in Polycystic Kidney Disease
The mechanosenory and chemosensory functions will be analyzed in regards to ADPKD because both structural and functional defects in primary cilia result in cystic kidney disease and vascular hypertension.
Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells
- Viralkumar S. Upadhyay, Brian S Muntean, Sarmed H. Kathem, J. Hwang, Wissam AbouAlaiwi, S. Nauli
- Biology, MedicineFrontiers in Physiology
- 26 February 2014
The studies suggest for the first time that dopamine or fenoldopam is an exciting agent that enhances structure and function of primary cilia and proposes that dopaminergic agents can be used in “cilio-therapy” to treat diseases associated with abnormal cilia structure and/or function.
Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles.
The cilia-targeted (CT) delivery system to deliver fenoldopam specifically to the primary cilia significantly improved cardiac function in the ciliopathic hypertensive models, and indicated that ciliotherapy provides a possibility toward personalized medicine in ciliopathy patients.
Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension.
Two studies provided scientific evidence that existing pharmacological agent could be personalized with advanced nanomaterials to treat ciliopathy by targeting cilia without the need of generating new drugs.
Mentha piperita Oil Exerts an Antiepileptic Effect in Pilocarpine and Pentylenetetrazol-Induced Seizures in Mice
- Waleed K. Abdulsahib, Sarmed H. Kathem, M. Y. Al-Radeef, L. Jasim
- Medicine, BiologyVeterinary Medicine International
- 22 September 2022
Peppermint essential oil at 3.2 and 6.4 ml/kg doses can reduce the percentage and the number of convulsions and increase the latency time of both the first convulsion and death so that it can be used as a supplement in the treatment of epilepsy.
Dopaminergic signaling within the primary cilia in the renovascular system
- Kimberly F. Atkinson, Sarmed H. Kathem, S. Nauli
- Medicine, BiologyFrontiers in Physiology
- 16 April 2015
It is shown that selective activation of DR5 specifically induces calcium influx only in the primary cilia, whereas non-selective activation of dopamine receptor induces calcium fluxes in both cilioplasm and cytoplasm, which leads to a greater response to fluid-shear stress.
Tolerable Ocular Hypotensive Effect of Topically Applied Sildenafil in Ocular in Normotensive and Betamethasone-Induced Hypertensive Rabbits
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Measuring depression and anxiety prevalence among Iraqi healthcare college students using hospital anxiety and depression scale
- Sarmed H. Kathem, Ali Azeez Al-Jumail, Malak Noor-Aldeen, Noor Najah, Dema Ali Khalid
- Psychology, MedicinePharmacy in practice
- 7 May 2021
Pharmacy and medical students may be vulnerable to depression and anxiety because of long study hours and may need more social support, more exercise, more sleep, less social media use and a lower academic workload to reduce their levels of anxiety and depression.
Capillary endothelia from two ADPKD patients are polyploidy.
- Sarmed H. Kathem, Wissam AbouAlaiwi, X. Zi, S. Nauli
- Biology, MedicineAnnals of clinical cytology and pathology
It is shown that endothelia from the renal capillary beds of two ADPKD patients are also polyploidy, and it is suggested that polyploidsy may be used as a potential cellular marker in AD PKD.