Sarla Naglot

  • Citations Per Year
Learn More
The currently prescribed tests for asthma diagnosis require compulsory patient compliance, and are usually not sensitive to mild asthma. Development of an objective test using minimally invasive samples for diagnosing and monitoring of the response of asthma may help better management of the disease. Raman spectroscopy (RS) has previously shown potential in(More)
YKL-40 is a chitinase like protein associated with inflammation in asthma. The role of single nucleotide polymorphisms in CHI3L1 gene on asthma susceptibility and YKL-40 levels has been widely investigated on different ethnic groups, and contradictory results were obtained on susceptibility allele. In the present study, surface plasmon resonance technology(More)
BACKGROUND Many studies reported for estimating serum YKL-40 using ELISA or RIA methods. This study introduces the plausible utilization of real-time surface plasmon resonance (SPR) technology in investigating the expression of serum YKL-40 protein levels and ELISA method for serum IgE in bronchial asthma. METHODS A commercially available BIAcore 2000(More)
Background: The evolutionary conserved 18 glycosyl hydrolase family contains chitinases and chitinase like proteins that share amino acid sequence homology with true chitinases but lack enzymatic activity. The chitinase like protein YKL-40, encoded by the chitinase3-like 1 gene (CHI3L1), has been found to be either the cause or a biomarker for asthma.(More)
  • 1