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Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling
Wnt signaling plays an important role in developmental and stem cell biology. To test the hypothesis that temporary inhibition of Wnt signaling will enhance granulation tissue and promoteExpand
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Inhibition of Wnt/β‐catenin pathway promotes regenerative repair of cutaneous and cartilage injury
Wound healing in mammals is a fibrotic process. The mechanisms driving fibrotic (as opposed to regenerative) repair are poorly understood. Herein we report that therapeutic Wnt inhibition withExpand
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sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair*
Transplantation of mesenchymal stem cells (MSCs) is a promising therapy for ischemic injury; however, inadequate survival of implanted cells in host tissue is a substantial impediment in the progressExpand
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Human Mesenchymal Stromal Cells: Identifying Assays to Predict Potency for Therapeutic Selection
Multipotent mesenchymal stromal cells (MSCs) have the potential to repair and regenerate damaged tissues, making them attractive candidates for cell‐based therapies. To maximize efficacy of MSCs,Expand
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Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct.
AIMS The WNT/β-catenin pathway is temporarily activated in the heart following myocardial infarction (MI). Despite data from genetic models indicating both positive and negative roles for the WNTExpand
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Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs)
We and others have found that Wnt signaling inhibition is important in mesenchymal stem cell (MSC) self‐renewal. Pyrvinium was identified as a potent Wnt inhibitor in a chemical screen for smallExpand
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Molecular cloning and characterization of a porcine UL16 binding protein (ULBP)-like cDNA.
UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibitedExpand
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Prolonged Hypoxia Induces Monocarboxylate Transporter‐4 Expression in Mesenchymal Stem Cells Resulting in a Secretome that is Deleterious to Cardiovascular Repair
MSCs encounter extended hypoxia in the wound microenvironment yet little is known about their adaptability to this prolonged hypoxic milieu. In this study, we evaluated the cellular and molecularExpand
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Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiologicalExpand
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Molecular mediators of mesenchymal stem cell biology.
Mesenchymal stem cells (MSCs) have the ability to self-renew and differentiate into multiple lineages making them an appropriate candidate for stem cell therapy. In spite of achieving considerableExpand
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