Sari Suomela

Outi Elomaa3
Jyrki Vuola2
3Outi Elomaa
2Jyrki Vuola
2Tiina Skoog
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BACKGROUND Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases. METHODS We studied association of single-nucleotide variants in IL23R with IBD in(More)
  • Sari Suomela, Outi Elomaa, Tiina Skoog, Risto Ala-aho, Leila Jeskanen, Jenita Pärssinen +5 others
  • 2009
Despite chronic inflammation, psoriatic lesions hardly ever progress to skin cancer. Aberrant function of the CCHCR1 gene (Coiled-Coil alpha-Helical Rod protein 1, HCR) within the PSORS1 locus may contribute to the onset of psoriasis. As CCHCR1 is expressed in certain cancers and regulates keratinocyte (KC) proliferation in a transgenic mouse model, we(More)
  • Mari H. Tervaniemi, H. Annika Siitonen, Cilla Söderhäll, Gurinder Minhas, Jyrki Vuola, Inkeri Tiala +5 others
  • 2012
CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC. Although its expression pattern in psoriatic skin differs from healthy skin and its overexpression influences cell proliferation in transgenic mice, its role as a psoriasis(More)
Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-end RNA sequencing. We found that(More)
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