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Epidermal neural crest stem cells (EPI-NCSCs) in the bulge of hair follicles are a promising source for cell-replacement therapies in neurodegenerative diseases. A prominent factor in cell-based therapy is the practicalities of different routes of administration. Cerebrospinal fluid (CSF), owing to its adaptive library of secreted growth factors, can(More)
Insulin-like growth factor-1 (IGF-1) is a potent neurotrophic factor that promotes the proliferation, migration and differentiation of glial and neuronal cells. IGF-1 can also protect neurons from undergoing apoptotic cell death. IGF-1 is produced by the choroid plexus, located in the ventricles. Knowledge of embryonic CSF composition at different(More)
he role of the cerebrospinal fluid (CSF) as a transport medium for biologically and behaviorally active hormones, drugs, and other such molecules has become increasingly evident over the past decade. It is a good sample for the reflection of biological changes inside the brain (1). Several studies have utilized different methods for collecting the CSF from(More)
OBJECTIVE Spinal cord injury (SCI) is a devastating condition causing neuronal loss. A key challenge in treatment of SCI is how to retain neurons after injury. Valproic acid (VPA) is a drug recently has been appreciated for its neuroprotective and neurotrophic properties in various SCI models. In this study the role of VPA was assessed in organotypic spinal(More)
AIM To evaluate the effects of long-term, moderate level noise exposure during crucial periods of rat infants on stereological parameters of medial geniculate body (MGB) and auditory cortex. MATERIALS AND METHODS Twenty-four male offspring of 12 pregnant rats were divided into four groups: fetal-to-critical period group, which were exposed to noise from(More)
BACKGROUND Alzheimer's disease (AD) is characterized by progressive and irreversible cognitive and memory impairment. The discovery of familial forms of AD (fAD) in association with specific gene mutations facilitated the generation of numerous rodent models. These models in turn proved valuable for the study of molecular mechanisms underlying AD(More)
Recent improvements in organotypic slice culturing and its accompanying technological innovations have made this biological preparation increasingly useful ex vivo experimental model. Among organotypic slice cultures obtained from various central nervous regions, spinal cord slice culture is an absorbing model that represents several unique advantages over(More)
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